Alton KB - Search Results

1

Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist.

Ghosal A, Lu X, Penner N, Gao L, Ramanathan R, Chowdhury SK, Kishnani NS, Alton KB. Ghosal A, et al. Among authors: alton kb. Drug Metab Dispos. 2011 Jan;39(1):30-8. doi: 10.1124/dmd.110.035493. Epub 2010 Oct 6. Drug Metab Dispos. 2011. PMID: 20926621

2

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).

Ghosal A, Hapangama N, Yuan Y, Achanfuo-Yeboah J, Iannucci R, Chowdhury S, Alton K, Patrick JE, Zbaida S. Ghosal A, et al. Drug Metab Dispos. 2004 Feb;32(2):267-71. doi: 10.1124/dmd.32.2.267. Drug Metab Dispos. 2004. PMID: 14744950

3

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).

Ghosal A, Hapangama N, Yuan Y, Achanfuo-Yeboah J, Iannucci R, Chowdhury S, Alton K, Patrick JE, Zbaida S. Ghosal A, et al. Drug Metab Dispos. 2004 Mar;32(3):314-20. doi: 10.1124/dmd.32.3.314. Drug Metab Dispos. 2004. PMID: 14977865

4

Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist.

Ghosal A, Ramanathan R, Yuan Y, Hapangama N, Chowdhury SK, Kishnani NS, Alton KB. Ghosal A, et al. Among authors: alton kb. Drug Metab Dispos. 2007 Dec;35(12):2186-95. doi: 10.1124/dmd.107.017517. Epub 2007 Sep 7. Drug Metab Dispos. 2007. PMID: 17827338

5

Metabolism of loratadine and further characterization of its in vitro metabolites.

Ghosal A, Gupta S, Ramanathan R, Yuan Y, Lu X, Su AD, Alvarez N, Zbaida S, Chowdhury SK, Alton KB. Ghosal A, et al. Among authors: alton kb. Drug Metab Lett. 2009 Aug;3(3):162-70. doi: 10.2174/187231209789352067. Epub 2009 Aug 1. Drug Metab Lett. 2009. PMID: 19702548

6

Identification of two novel metabolites of SCH 486757, a nociceptin/orphanin FQ peptide receptor agonist, in humans.

Penner NA, Ho G, Bercovici A, Chowdhury SK, Alton KB. Penner NA, et al. Among authors: alton kb. Drug Metab Dispos. 2010 Nov;38(11):2067-74. doi: 10.1124/dmd.110.032516. Epub 2010 Jul 29. Drug Metab Dispos. 2010. PMID: 20671096

7

Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor.

Ghosal A, Yuan Y, Tong W, Su AD, Gu C, Chowdhury SK, Kishnani NS, Alton KB. Ghosal A, et al. Among authors: alton kb. Drug Metab Dispos. 2011 Mar;39(3):510-21. doi: 10.1124/dmd.110.036996. Epub 2010 Dec 1. Drug Metab Dispos. 2011. PMID: 21123164

8

Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 351125, a CCR5 antagonist.

Ghosal A, Chowdhury SK, Gupta S, Yuan Y, Iannucci R, Zhang H, Zbaida S, Patrick JE, Alton KB. Ghosal A, et al. Among authors: alton kb. Xenobiotica. 2005 May;35(5):405-17. doi: 10.1080/00498250500136569. Xenobiotica. 2005. PMID: 16012074

9

Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects.

Patrick JE, Kosoglou T, Stauber KL, Alton KB, Maxwell SE, Zhu Y, Statkevich P, Iannucci R, Chowdhury S, Affrime M, Cayen MN. Patrick JE, et al. Among authors: alton kb. Drug Metab Dispos. 2002 Apr;30(4):430-7. doi: 10.1124/dmd.30.4.430. Drug Metab Dispos. 2002. PMID: 11901097 Clinical Trial.

10

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.

Ghosal A, Yuan Y, Hapangama N, Su AD, Alvarez N, Chowdhury SK, Alton KB, Patrick JE, Zbaida S. Ghosal A, et al. Among authors: alton kb. Biopharm Drug Dispos. 2004 Sep;25(6):243-52. doi: 10.1002/bdd.405. Biopharm Drug Dispos. 2004. PMID: 15334623

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