Rose-John S - Search Results

1

A role for IL-27p28 as an antagonist of gp130-mediated signaling.

Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O'Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, Jones SA, Elloso MM, Grötzinger J, Cancro MP, Levin SD, Hunter CA. Stumhofer JS, et al. Nat Immunol. 2010 Dec;11(12):1119-26. doi: 10.1038/ni.1957. Epub 2010 Nov 7. Nat Immunol. 2010. PMID: 21057510 Free PMC article.

2

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

Ehlers M, Grötzinger J, deHon FD, Müllberg J, Brakenhoff JP, Liu J, Wollmer A, Rose-John S. Ehlers M, et al. J Immunol. 1994 Aug 15;153(4):1744-53. J Immunol. 1994. PMID: 7519211

3

Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130.

de Hon FD, Klaasse Bos HK, Ebeling SB, Grötzinger J, Kurapkat G, Rose-John S, Aarden LA, Brakenhoff JP. de Hon FD, et al. FEBS Lett. 1995 Aug 7;369(2-3):187-91. doi: 10.1016/0014-5793(95)00741-q. FEBS Lett. 1995. PMID: 7649255 Free article.

4

Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.

Ehlers M, de Hon FD, Bos HK, Horsten U, Kurapkat G, van De Leur HS, Grötzinger J, Wollmer A, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Biol Chem. 1995 Apr 7;270(14):8158-63. doi: 10.1074/jbc.270.14.8158. J Biol Chem. 1995. PMID: 7713920 Free article.

5

Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation.

Ehlers M, Grötzinger J, Fischer M, Bos HK, Brakenhoff JP, Rose-John S. Ehlers M, et al. J Interferon Cytokine Res. 1996 Aug;16(8):569-76. doi: 10.1089/jir.1996.16.569. J Interferon Cytokine Res. 1996. PMID: 8877726

6

Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.

Brakenhoff JP, Bos HK, Grötzinger J, Rose-John S, Aarden LA. Brakenhoff JP, et al. FEBS Lett. 1996 Oct 21;395(2-3):235-40. doi: 10.1016/0014-5793(96)00974-x. FEBS Lett. 1996. PMID: 8898103 Free article.

7

I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion.

Fischer M, Goldschmitt J, Peschel C, Brakenhoff JP, Kallen KJ, Wollmer A, Grötzinger J, Rose-John S. Fischer M, et al. Nat Biotechnol. 1997 Feb;15(2):142-5. doi: 10.1038/nbt0297-142. Nat Biotechnol. 1997. PMID: 9035138

8

The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes.

Grötzinger J, Kurapkat G, Wollmer A, Kalai M, Rose-John S. Grötzinger J, et al. Proteins. 1997 Jan;27(1):96-109. Proteins. 1997. PMID: 9037715

9

The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.

Ozbek S, Grötzinger J, Krebs B, Fischer M, Wollmer A, Jostock T, Müllberg J, Rose-John S. Ozbek S, et al. J Biol Chem. 1998 Aug 14;273(33):21374-9. doi: 10.1074/jbc.273.33.21374. J Biol Chem. 1998. PMID: 9694899 Free article.

10

A new type of cytokine receptor antagonist directly targeting gp130.

Renné C, Kallen KJ, Müllberg J, Jostock T, Grötzinger J, Rose-John S. Renné C, et al. J Biol Chem. 1998 Oct 16;273(42):27213-9. doi: 10.1074/jbc.273.42.27213. J Biol Chem. 1998. PMID: 9765242 Free article.

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