Snyders DJ - Search Results

1

The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.

Labro AJ, Boulet IR, Choveau FS, Mayeur E, Bruyns T, Loussouarn G, Raes AL, Snyders DJ. Labro AJ, et al. Among authors: snyders dj. J Biol Chem. 2011 Jan 7;286(1):717-25. doi: 10.1074/jbc.M110.146977. Epub 2010 Nov 8. J Biol Chem. 2011. PMID: 21059661 Free PMC article.

2

Role of the S6 C-terminus in KCNQ1 channel gating.

Boulet IR, Labro AJ, Raes AL, Snyders DJ. Boulet IR, et al. Among authors: snyders dj. J Physiol. 2007 Dec 1;585(Pt 2):325-37. doi: 10.1113/jphysiol.2007.145813. Epub 2007 Oct 11. J Physiol. 2007. PMID: 17932138 Free PMC article.

3

A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ. Labro AJ, et al. Among authors: snyders dj. Am J Physiol Cell Physiol. 2008 Jun;294(6):C1476-84. doi: 10.1152/ajpcell.00479.2007. Epub 2008 Apr 2. Am J Physiol Cell Physiol. 2008. PMID: 18385285 Free article.

4

Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.

Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ. Labro AJ, et al. Among authors: snyders dj. J Gen Physiol. 2008 Dec;132(6):667-80. doi: 10.1085/jgp.200810048. J Gen Physiol. 2008. PMID: 19029374 Free PMC article.

5

Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.

Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ. Bocksteins E, et al. Among authors: snyders dj. J Biol Chem. 2009 Nov 13;284(46):31625-34. doi: 10.1074/jbc.M109.039479. Epub 2009 Aug 28. J Biol Chem. 2009. PMID: 19717558 Free PMC article.

6

The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.

Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ. Labro AJ, et al. Among authors: snyders dj. J Mol Cell Cardiol. 2010 Jun;48(6):1096-104. doi: 10.1016/j.yjmcc.2009.10.027. Epub 2009 Nov 11. J Mol Cell Cardiol. 2010. PMID: 19913547 Review.

7

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G. Choveau FS, et al. Among authors: snyders dj. J Biol Chem. 2011 Jan 7;286(1):707-16. doi: 10.1074/jbc.M110.146324. Epub 2010 Oct 12. J Biol Chem. 2011. PMID: 20940310 Free PMC article.

8

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.

Martinez-Morales E, Snyders DJ, Labro AJ. Martinez-Morales E, et al. Among authors: snyders dj. Biophys J. 2014 Jan 7;106(1):134-44. doi: 10.1016/j.bpj.2013.11.025. Biophys J. 2014. PMID: 24411245 Free PMC article.

9

Gating of shaker-type channels requires the flexibility of S6 caused by prolines.

Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ. Labro AJ, et al. Among authors: snyders dj. J Biol Chem. 2003 Dec 12;278(50):50724-31. doi: 10.1074/jbc.M306097200. Epub 2003 Sep 17. J Biol Chem. 2003. PMID: 13679372 Free article.

10

Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels.

Labro AJ, Raes AL, Snyders DJ. Labro AJ, et al. Among authors: snyders dj. J Gen Physiol. 2005 Jan;125(1):71-80. doi: 10.1085/jgp.200409194. J Gen Physiol. 2005. PMID: 15623896 Free PMC article.

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