Maloney DJ - Search Results

1

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.

Dorjsuren D, Kim D, Maloney DJ, Wilson DM 3rd, Simeonov A. Dorjsuren D, et al. Among authors: maloney dj. Nucleic Acids Res. 2011 Jan;39(2):e11. doi: 10.1093/nar/gkq1082. Epub 2010 Nov 9. Nucleic Acids Res. 2011. PMID: 21062821 Free PMC article.

2

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

Dorjsuren D, Kim D, Vyjayanti VN, Maloney DJ, Jadhav A, Wilson DM 3rd, Simeonov A. Dorjsuren D, et al. Among authors: maloney dj. PLoS One. 2012;7(10):e47974. doi: 10.1371/journal.pone.0047974. Epub 2012 Oct 23. PLoS One. 2012. PMID: 23110144 Free PMC article.

3

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM 3rd, Maloney DJ. Rai G, et al. Among authors: maloney dj. J Med Chem. 2012 Apr 12;55(7):3101-12. doi: 10.1021/jm201537d. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22455312 Free PMC article.

4

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.

Yasgar A, Furdas SD, Maloney DJ, Jadhav A, Jung M, Simeonov A. Yasgar A, et al. Among authors: maloney dj. PLoS One. 2012;7(9):e45594. doi: 10.1371/journal.pone.0045594. Epub 2012 Sep 20. PLoS One. 2012. PMID: 23029124 Free PMC article.

5

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.

Abdel-Fatah TM, Russell R, Albarakati N, Maloney DJ, Dorjsuren D, Rueda OM, Moseley P, Mohan V, Sun H, Abbotts R, Mukherjee A, Agarwal D, Illuzzi JL, Jadhav A, Simeonov A, Ball G, Chan S, Caldas C, Ellis IO, Wilson DM 3rd, Madhusudan S. Abdel-Fatah TM, et al. Among authors: maloney dj. Mol Oncol. 2014 Oct;8(7):1326-38. doi: 10.1016/j.molonc.2014.04.009. Epub 2014 May 13. Mol Oncol. 2014. PMID: 24880630 Free PMC article.

6

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.

Poletto M, Malfatti MC, Dorjsuren D, Scognamiglio PL, Marasco D, Vascotto C, Jadhav A, Maloney DJ, Wilson DM 3rd, Simeonov A, Tell G. Poletto M, et al. Among authors: maloney dj. Mol Carcinog. 2016 May;55(5):688-704. doi: 10.1002/mc.22313. Epub 2015 Apr 11. Mol Carcinog. 2016. PMID: 25865359 Free PMC article.

7

Inhibition of DNA glycosylases via small molecule purine analogs.

Jacobs AC, Calkins MJ, Jadhav A, Dorjsuren D, Maloney D, Simeonov A, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS. Jacobs AC, et al. PLoS One. 2013 Dec 9;8(12):e81667. doi: 10.1371/journal.pone.0081667. eCollection 2013. PLoS One. 2013. PMID: 24349107 Free PMC article.

8

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A. Jadhav A, et al. Among authors: maloney dj. J Med Chem. 2010 Jan 14;53(1):37-51. doi: 10.1021/jm901070c. J Med Chem. 2010. PMID: 19908840 Free PMC article.

9

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124.

Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Auld DS, et al. Among authors: maloney dj. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4878-83. doi: 10.1073/pnas.0909141107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194791 Free PMC article.

10

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ. Rosenthal AS, et al. Among authors: maloney dj. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6. doi: 10.1016/j.bmcl.2013.08.025. Epub 2013 Aug 13. Bioorg Med Chem Lett. 2013. PMID: 24012121 Free PMC article.

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