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Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Lamoral-Theys D, Andolfi A, Van Goietsenoven G, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, Mathieu V, Kornienko A, Kiss R, Evidente A. Lamoral-Theys D, et al. Among authors: gras t. J Med Chem. 2009 Oct 22;52(20):6244-56. doi: 10.1021/jm901031h. J Med Chem. 2009. PMID: 19788245 Free PMC article.
Potential anticancer activity of young Carpinus betulus leaves.
Cieckiewicz E, Angenot L, Gras T, Kiss R, Frédérich M. Cieckiewicz E, et al. Among authors: gras t. Phytomedicine. 2012 Feb 15;19(3-4):278-83. doi: 10.1016/j.phymed.2011.09.072. Epub 2011 Oct 19. Phytomedicine. 2012. PMID: 22014503
Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.
Le Calvé B, Rynkowski M, Le Mercier M, Bruyère C, Lonez C, Gras T, Haibe-Kains B, Bontempi G, Decaestecker C, Ruysschaert JM, Kiss R, Lefranc F. Le Calvé B, et al. Among authors: gras t. Neoplasia. 2010 Sep;12(9):727-39. doi: 10.1593/neo.10526. Neoplasia. 2010. PMID: 20824049 Free PMC article.
19 results