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Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V, Nachon F, Hroudova J, Fisar Z, Kuca K. Korabecny J, et al. Among authors: nepovimova e. Molecules. 2010 Dec 2;15(12):8804-12. doi: 10.3390/molecules15128804. Molecules. 2010. PMID: 21127466 Free PMC article.
From pyridinium-based to centrally active acetylcholinesterase reactivators.
Korabecny J, Soukup O, Dolezal R, Spilovska K, Nepovimova E, Andrs M, Nguyen TD, Jun D, Musilek K, Kucerova-Chlupacova M, Kuca K. Korabecny J, et al. Among authors: nepovimova e. Mini Rev Med Chem. 2014;14(3):215-21. doi: 10.2174/1389557514666140219103138. Mini Rev Med Chem. 2014. PMID: 24552265 Review.
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Korabecny J, Dolezal R, Cabelova P, Horova A, Hruba E, Ricny J, Sedlacek L, Nepovimova E, Spilovska K, Andrs M, Musilek K, Opletalova V, Sepsova V, Ripova D, Kuca K. Korabecny J, et al. Among authors: nepovimova e. Eur J Med Chem. 2014 Jul 23;82:426-38. doi: 10.1016/j.ejmech.2014.05.066. Epub 2014 May 27. Eur J Med Chem. 2014. PMID: 24929293
Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects.
Nepovimova E, Uliassi E, Korabecny J, Peña-Altamira LE, Samez S, Pesaresi A, Garcia GE, Bartolini M, Andrisano V, Bergamini C, Fato R, Lamba D, Roberti M, Kuca K, Monti B, Bolognesi ML. Nepovimova E, et al. J Med Chem. 2014 Oct 23;57(20):8576-89. doi: 10.1021/jm5010804. Epub 2014 Oct 10. J Med Chem. 2014. PMID: 25259726
The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test.
Misik J, Korabecny J, Nepovimova E, Cabelova P, Kassa J. Misik J, et al. Among authors: nepovimova e. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Dec;159(4):547-53. doi: 10.5507/bp.2015.006. Epub 2015 Feb 10. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015. PMID: 25690521 Free article.
205 results