Chang Y - Search Results

1

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.

Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Levy D, et al. Among authors: chang y. Nat Immunol. 2011 Jan;12(1):29-36. doi: 10.1038/ni.1968. Epub 2010 Dec 5. Nat Immunol. 2011. PMID: 21131967 Free PMC article.

2

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.

Chang Y, Levy D, Horton JR, Peng J, Zhang X, Gozani O, Cheng X. Chang Y, et al. Nucleic Acids Res. 2011 Aug;39(15):6380-9. doi: 10.1093/nar/gkr256. Epub 2011 Apr 22. Nucleic Acids Res. 2011. PMID: 21515635 Free PMC article.

3

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.

Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X. Chang Y, et al. Nat Commun. 2011 Nov 15;2:533. doi: 10.1038/ncomms1549. Nat Commun. 2011. PMID: 22086334 Free PMC article.

4

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Chang Y, et al. Nat Struct Mol Biol. 2009 Mar;16(3):312-7. doi: 10.1038/nsmb.1560. Epub 2009 Feb 15. Nat Struct Mol Biol. 2009. PMID: 19219047 Free PMC article.

5

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.

Chang Y, Horton JR, Bedford MT, Zhang X, Cheng X. Chang Y, et al. J Mol Biol. 2011 May 20;408(5):807-14. doi: 10.1016/j.jmb.2011.03.018. Epub 2011 Mar 23. J Mol Biol. 2011. PMID: 21419134 Free PMC article.

6

Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X. Chang Y, et al. J Mol Biol. 2010 Jul 2;400(1):1-7. doi: 10.1016/j.jmb.2010.04.048. Epub 2010 Apr 29. J Mol Biol. 2010. PMID: 20434463 Free PMC article.

7

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.

Estève PO, Chang Y, Samaranayake M, Upadhyay AK, Horton JR, Feehery GR, Cheng X, Pradhan S. Estève PO, et al. Among authors: chang y. Nat Struct Mol Biol. 2011 Jan;18(1):42-8. doi: 10.1038/nsmb.1939. Epub 2010 Dec 12. Nat Struct Mol Biol. 2011. PMID: 21151116 Free PMC article.

8

An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.

Upadhyay AK, Rotili D, Han JW, Hu R, Chang Y, Labella D, Zhang X, Yoon YS, Mai A, Cheng X. Upadhyay AK, et al. Among authors: chang y. J Mol Biol. 2012 Feb 24;416(3):319-27. doi: 10.1016/j.jmb.2011.12.036. Epub 2011 Dec 29. J Mol Biol. 2012. PMID: 22227394 Free PMC article.

9

Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.

Rotili D, Tarantino D, Marrocco B, Gros C, Masson V, Poughon V, Ausseil F, Chang Y, Labella D, Cosconati S, Di Maro S, Novellino E, Schnekenburger M, Grandjenette C, Bouvy C, Diederich M, Cheng X, Arimondo PB, Mai A. Rotili D, et al. Among authors: chang y. PLoS One. 2014 May 8;9(5):e96941. doi: 10.1371/journal.pone.0096941. eCollection 2014. PLoS One. 2014. PMID: 24810902 Free PMC article.

10

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.

Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X. Hashimoto H, et al. Among authors: chang y. Nucleic Acids Res. 2012 Jun;40(11):4841-9. doi: 10.1093/nar/gks155. Epub 2012 Feb 22. Nucleic Acids Res. 2012. PMID: 22362737 Free PMC article.

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