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Page 1
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Levy D, et al. Among authors: schaefer u. Nat Immunol. 2011 Jan;12(1):29-36. doi: 10.1038/ni.1968. Epub 2010 Dec 5. Nat Immunol. 2011. PMID: 21131967 Free PMC article.
Suppression of the antiviral response by an influenza histone mimic.
Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A. Marazzi I, et al. Among authors: schaefer u. Nature. 2012 Mar 14;483(7390):428-33. doi: 10.1038/nature10892. Nature. 2012. PMID: 22419161 Free PMC article.
The "histone mimicry" by pathogens.
Schaefer U, Ho JS, Prinjha RK, Tarakhovsky A. Schaefer U, et al. Cold Spring Harb Symp Quant Biol. 2013;78:81-90. doi: 10.1101/sqb.2013.78.020339. Epub 2014 Apr 14. Cold Spring Harb Symp Quant Biol. 2013. PMID: 24733380 Free PMC article.
Suppression of inflammation by a synthetic histone mimic.
Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. Nicodeme E, et al. Among authors: schaefer u. Nature. 2010 Dec 23;468(7327):1119-23. doi: 10.1038/nature09589. Epub 2010 Nov 10. Nature. 2010. PMID: 21068722 Free PMC article.
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response.
Fang TC, Schaefer U, Mecklenbrauker I, Stienen A, Dewell S, Chen MS, Rioja I, Parravicini V, Prinjha RK, Chandwani R, MacDonald MR, Lee K, Rice CM, Tarakhovsky A. Fang TC, et al. Among authors: schaefer u. J Exp Med. 2012 Apr 9;209(4):661-9. doi: 10.1084/jem.20112343. Epub 2012 Mar 12. J Exp Med. 2012. PMID: 22412156 Free PMC article.
Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells.
Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D. Yoshida H, et al. Among authors: schaefer u. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):E4448-57. doi: 10.1073/pnas.1512081112. Epub 2015 Jul 27. Proc Natl Acad Sci U S A. 2015. PMID: 26216992 Free PMC article.
Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.
Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A. Sullivan JM, et al. Among authors: schaefer a, schaefer u. J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21. J Exp Med. 2015. PMID: 26392221 Free PMC article.
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.
Halper-Stromberg A, Lu CL, Klein F, Horwitz JA, Bournazos S, Nogueira L, Eisenreich TR, Liu C, Gazumyan A, Schaefer U, Furze RC, Seaman MS, Prinjha R, Tarakhovsky A, Ravetch JV, Nussenzweig MC. Halper-Stromberg A, et al. Among authors: schaefer u. Cell. 2014 Aug 28;158(5):989-999. doi: 10.1016/j.cell.2014.07.043. Epub 2014 Aug 14. Cell. 2014. PMID: 25131989 Free PMC article.
The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response.
Seifert LL, Si C, Saha D, Sadic M, de Vries M, Ballentine S, Briley A, Wang G, Valero-Jimenez AM, Mohamed A, Schaefer U, Moulton HM, García-Sastre A, Tripathi S, Rosenberg BR, Dittmann M. Seifert LL, et al. Among authors: schaefer u. PLoS Pathog. 2019 Nov 4;15(11):e1007634. doi: 10.1371/journal.ppat.1007634. eCollection 2019 Nov. PLoS Pathog. 2019. PMID: 31682641 Free PMC article.
439 results