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A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques.
Moldt B, Shibata-Koyama M, Rakasz EG, Schultz N, Kanda Y, Dunlop DC, Finstad SL, Jin C, Landucci G, Alpert MD, Dugast AS, Parren PW, Nimmerjahn F, Evans DT, Alter G, Forthal DN, Schmitz JE, Iida S, Poignard P, Watkins DI, Hessell AJ, Burton DR. Moldt B, et al. J Virol. 2012 Jun;86(11):6189-96. doi: 10.1128/JVI.00491-12. Epub 2012 Mar 28. J Virol. 2012. PMID: 22457527 Free PMC article.
Protection of Humanized Mice From Repeated Intravaginal HIV Challenge by Passive Immunization: A Model for Studying the Efficacy of Neutralizing Antibodies In Vivo.
Deruaz M, Moldt B, Le KM, Power KA, Vrbanac VD, Tanno S, Ghebremichael MS, Allen TM, Tager AM, Burton DR, Luster AD. Deruaz M, et al. Among authors: moldt b. J Infect Dis. 2016 Aug 15;214(4):612-6. doi: 10.1093/infdis/jiw203. Epub 2016 Jun 29. J Infect Dis. 2016. PMID: 27357340 Free PMC article.
SnapShot: broadly neutralizing antibodies.
Sok D, Moldt B, Burton DR. Sok D, et al. Among authors: moldt b. Cell. 2013 Oct 24;155(3):728-728.e1. doi: 10.1016/j.cell.2013.10.009. Epub 2013 Oct 24. Cell. 2013. PMID: 24243025 Free PMC article. No abstract available.
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. Barouch DH, et al. Among authors: moldt b. Nature. 2013 Nov 14;503(7475):224-8. doi: 10.1038/nature12744. Epub 2013 Oct 30. Nature. 2013. PMID: 24172905 Free PMC article.
39 results