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Page 1
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.
Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C. Jackson B, et al. Among authors: ladwein m. Mol Biol Cell. 2011 Mar 1;22(5):593-605. doi: 10.1091/mbc.E09-10-0859. Epub 2011 Jan 5. Mol Biol Cell. 2011. PMID: 21209320 Free PMC article.
Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation.
Steffen A, Ladwein M, Dimchev GA, Hein A, Schwenkmezger L, Arens S, Ladwein KI, Margit Holleboom J, Schur F, Victor Small J, Schwarz J, Gerhard R, Faix J, Stradal TE, Brakebusch C, Rottner K. Steffen A, et al. Among authors: ladwein m. J Cell Sci. 2013 Oct 15;126(Pt 20):4572-88. doi: 10.1242/jcs.118232. Epub 2013 Jul 31. J Cell Sci. 2013. PMID: 23902686 Free PMC article.
Serine-71 phosphorylation of Rac1 modulates downstream signaling.
Schwarz J, Proff J, Hävemeier A, Ladwein M, Rottner K, Barlag B, Pich A, Tatge H, Just I, Gerhard R. Schwarz J, et al. Among authors: ladwein m. PLoS One. 2012;7(9):e44358. doi: 10.1371/journal.pone.0044358. Epub 2012 Sep 10. PLoS One. 2012. PMID: 22970203 Free PMC article.
Molecular dissection of Salmonella-induced membrane ruffling versus invasion.
Hänisch J, Ehinger J, Ladwein M, Rohde M, Derivery E, Bosse T, Steffen A, Bumann D, Misselwitz B, Hardt WD, Gautreau A, Stradal TE, Rottner K. Hänisch J, et al. Among authors: ladwein m. Cell Microbiol. 2010 Jan;12(1):84-98. doi: 10.1111/j.1462-5822.2009.01380.x. Epub 2009 Sep 2. Cell Microbiol. 2010. PMID: 19732055
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