Garber E - Search Results

1

Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.

Pepinsky RB, Walus L, Shao Z, Ji B, Gu S, Sun Y, Wen D, Lee X, Wang Q, Garber E, Mi S. Pepinsky RB, et al. Among authors: garber e. Bioconjug Chem. 2011 Feb 16;22(2):200-10. doi: 10.1021/bc1002746. Epub 2011 Jan 21. Bioconjug Chem. 2011. PMID: 21254764

2

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.

Pepinsky RB, Silvian L, Berkowitz SA, Farrington G, Lugovskoy A, Walus L, Eldredge J, Capili A, Mi S, Graff C, Garber E. Pepinsky RB, et al. Among authors: garber e. Protein Sci. 2010 May;19(5):954-66. doi: 10.1002/pro.372. Protein Sci. 2010. PMID: 20198683 Free PMC article.

3

Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

Pepinsky RB, Shao Z, Ji B, Wang Q, Meng G, Walus L, Lee X, Hu Y, Graff C, Garber E, Meier W, Mi S. Pepinsky RB, et al. Among authors: garber e. J Pharmacol Exp Ther. 2011 Nov;339(2):519-29. doi: 10.1124/jpet.111.183483. Epub 2011 Aug 1. J Pharmacol Exp Ther. 2011. PMID: 21807883

4

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.

Mi S, Hu B, Hahm K, Luo Y, Kam Hui ES, Yuan Q, Wong WM, Wang L, Su H, Chu TH, Guo J, Zhang W, So KF, Pepinsky B, Shao Z, Graff C, Garber E, Jung V, Wu EX, Wu W. Mi S, et al. Among authors: garber e. Nat Med. 2007 Oct;13(10):1228-33. doi: 10.1038/nm1664. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906634

5

Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells.

Wen D, Vecchi MM, Gu S, Su L, Dolnikova J, Huang YM, Foley SF, Garber E, Pederson N, Meier W. Wen D, et al. Among authors: garber e. J Biol Chem. 2009 Nov 20;284(47):32686-94. doi: 10.1074/jbc.M109.059360. Epub 2009 Sep 25. J Biol Chem. 2009. PMID: 19783658 Free PMC article.

6

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.

Pepinsky RB, Shapiro RI, Wang S, Chakraborty A, Gill A, Lepage DJ, Wen D, Rayhorn P, Horan GS, Taylor FR, Garber EA, Galdes A, Engber TM. Pepinsky RB, et al. J Pharm Sci. 2002 Feb;91(2):371-87. doi: 10.1002/jps.10052. J Pharm Sci. 2002. PMID: 11835197

7

Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering.

Weinreb PH, Wen D, Qian F, Wildes CP, Garber EA, Walus L, Jung MY, Wang J, Relton JK, Amatucci J, Wang R, Porreca F, Silvian L, Meier W, Pepinsky RB, Lee DH. Weinreb PH, et al. Biotechnol Appl Biochem. 2010 Sep;57(1):31-45. doi: 10.1042/BA20100061. Biotechnol Appl Biochem. 2010. PMID: 20815818

8

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4.

Shapiro RI, Plavina T, Schlain BR, Pepinsky RB, Garber EA, Jarpe M, Hochman PS, Wehner NG, Bard F, Motter R, Yednock TA, Taylor FR. Shapiro RI, et al. J Pharm Biomed Anal. 2011 Apr 28;55(1):168-75. doi: 10.1016/j.jpba.2011.01.006. Epub 2011 Jan 19. J Pharm Biomed Anal. 2011. PMID: 21300512

9

Mapping sonic hedgehog-receptor interactions by steric interference.

Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA. Pepinsky RB, et al. Among authors: garber ea. J Biol Chem. 2000 Apr 14;275(15):10995-1001. doi: 10.1074/jbc.275.15.10995. J Biol Chem. 2000. PMID: 10753901 Free article.

10

Identification of a palmitic acid-modified form of human Sonic hedgehog.

Pepinsky RB, Zeng C, Wen D, Rayhorn P, Baker DP, Williams KP, Bixler SA, Ambrose CM, Garber EA, Miatkowski K, Taylor FR, Wang EA, Galdes A. Pepinsky RB, et al. Among authors: garber ea. J Biol Chem. 1998 May 29;273(22):14037-45. doi: 10.1074/jbc.273.22.14037. J Biol Chem. 1998. PMID: 9593755 Free article.

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