Mi S - Search Results

1

Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.

Pepinsky RB, Walus L, Shao Z, Ji B, Gu S, Sun Y, Wen D, Lee X, Wang Q, Garber E, Mi S. Pepinsky RB, et al. Among authors: mi s. Bioconjug Chem. 2011 Feb 16;22(2):200-10. doi: 10.1021/bc1002746. Epub 2011 Jan 21. Bioconjug Chem. 2011. PMID: 21254764

2

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.

Pepinsky RB, Silvian L, Berkowitz SA, Farrington G, Lugovskoy A, Walus L, Eldredge J, Capili A, Mi S, Graff C, Garber E. Pepinsky RB, et al. Among authors: mi s. Protein Sci. 2010 May;19(5):954-66. doi: 10.1002/pro.372. Protein Sci. 2010. PMID: 20198683 Free PMC article.

3

Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

Pepinsky RB, Shao Z, Ji B, Wang Q, Meng G, Walus L, Lee X, Hu Y, Graff C, Garber E, Meier W, Mi S. Pepinsky RB, et al. Among authors: mi s. J Pharmacol Exp Ther. 2011 Nov;339(2):519-29. doi: 10.1124/jpet.111.183483. Epub 2011 Aug 1. J Pharmacol Exp Ther. 2011. PMID: 21807883

4

Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic.

Mi S, Pepinsky RB, Cadavid D. Mi S, et al. CNS Drugs. 2013 Jul;27(7):493-503. doi: 10.1007/s40263-013-0068-8. CNS Drugs. 2013. PMID: 23681979 Review.

5

Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.

Pepinsky RB, Arndt JW, Quan C, Gao Y, Quintero-Monzon O, Lee X, Mi S. Pepinsky RB, et al. Among authors: mi s. J Pharmacol Exp Ther. 2014 Jul;350(1):110-23. doi: 10.1124/jpet.113.211771. Epub 2014 Apr 22. J Pharmacol Exp Ther. 2014. PMID: 24756303

6

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site.

Hanf KJM, Arndt JW, Liu Y, Gong BJ, Rushe M, Sopko R, Massol R, Smith B, Gao Y, Dalkilic-Liddle I, Lee X, Mojta S, Shao Z, Mi S, Pepinsky RB. Hanf KJM, et al. Among authors: mi s. MAbs. 2020 Jan-Dec;12(1):1713648. doi: 10.1080/19420862.2020.1713648. MAbs. 2020. PMID: 31928294 Free PMC article.

7

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB. Mi S, et al. Nat Neurosci. 2004 Mar;7(3):221-8. doi: 10.1038/nn1188. Epub 2004 Feb 15. Nat Neurosci. 2004. PMID: 14966521

8

TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration.

Shao Z, Browning JL, Lee X, Scott ML, Shulga-Morskaya S, Allaire N, Thill G, Levesque M, Sah D, McCoy JM, Murray B, Jung V, Pepinsky RB, Mi S. Shao Z, et al. Among authors: mi s. Neuron. 2005 Feb 3;45(3):353-9. doi: 10.1016/j.neuron.2004.12.050. Neuron. 2005. PMID: 15694322 Free article.

9

LINGO-1 negatively regulates myelination by oligodendrocytes.

Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB. Mi S, et al. Nat Neurosci. 2005 Jun;8(6):745-51. doi: 10.1038/nn1460. Epub 2005 May 15. Nat Neurosci. 2005. PMID: 15895088

10

LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury.

Ji B, Li M, Wu WT, Yick LW, Lee X, Shao Z, Wang J, So KF, McCoy JM, Pepinsky RB, Mi S, Relton JK. Ji B, et al. Among authors: mi s. Mol Cell Neurosci. 2006 Nov;33(3):311-20. doi: 10.1016/j.mcn.2006.08.003. Epub 2006 Sep 29. Mol Cell Neurosci. 2006. PMID: 17011208

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