Pepinsky RB - Search Results

1

Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.

Pepinsky RB, Walus L, Shao Z, Ji B, Gu S, Sun Y, Wen D, Lee X, Wang Q, Garber E, Mi S. Pepinsky RB, et al. Bioconjug Chem. 2011 Feb 16;22(2):200-10. doi: 10.1021/bc1002746. Epub 2011 Jan 21. Bioconjug Chem. 2011. PMID: 21254764

2

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis.

Pepinsky RB, Silvian L, Berkowitz SA, Farrington G, Lugovskoy A, Walus L, Eldredge J, Capili A, Mi S, Graff C, Garber E. Pepinsky RB, et al. Protein Sci. 2010 May;19(5):954-66. doi: 10.1002/pro.372. Protein Sci. 2010. PMID: 20198683 Free PMC article.

3

Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

Pepinsky RB, Shao Z, Ji B, Wang Q, Meng G, Walus L, Lee X, Hu Y, Graff C, Garber E, Meier W, Mi S. Pepinsky RB, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):519-29. doi: 10.1124/jpet.111.183483. Epub 2011 Aug 1. J Pharmacol Exp Ther. 2011. PMID: 21807883

4

Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.

Pepinsky RB, Arndt JW, Quan C, Gao Y, Quintero-Monzon O, Lee X, Mi S. Pepinsky RB, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):110-23. doi: 10.1124/jpet.113.211771. Epub 2014 Apr 22. J Pharmacol Exp Ther. 2014. PMID: 24756303

5

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site.

Hanf KJM, Arndt JW, Liu Y, Gong BJ, Rushe M, Sopko R, Massol R, Smith B, Gao Y, Dalkilic-Liddle I, Lee X, Mojta S, Shao Z, Mi S, Pepinsky RB. Hanf KJM, et al. Among authors: pepinsky rb. MAbs. 2020 Jan-Dec;12(1):1713648. doi: 10.1080/19420862.2020.1713648. MAbs. 2020. PMID: 31928294 Free PMC article.

6

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.

Pepinsky RB, Shapiro RI, Wang S, Chakraborty A, Gill A, Lepage DJ, Wen D, Rayhorn P, Horan GS, Taylor FR, Garber EA, Galdes A, Engber TM. Pepinsky RB, et al. J Pharm Sci. 2002 Feb;91(2):371-87. doi: 10.1002/jps.10052. J Pharm Sci. 2002. PMID: 11835197

7

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

Baker DP, Lin EY, Lin K, Pellegrini M, Petter RC, Chen LL, Arduini RM, Brickelmaier M, Wen D, Hess DM, Chen L, Grant D, Whitty A, Gill A, Lindner DJ, Pepinsky RB. Baker DP, et al. Among authors: pepinsky rb. Bioconjug Chem. 2006 Jan-Feb;17(1):179-88. doi: 10.1021/bc050237q. Bioconjug Chem. 2006. PMID: 16417267

8

LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury.

Ji B, Li M, Wu WT, Yick LW, Lee X, Shao Z, Wang J, So KF, McCoy JM, Pepinsky RB, Mi S, Relton JK. Ji B, et al. Among authors: pepinsky rb. Mol Cell Neurosci. 2006 Nov;33(3):311-20. doi: 10.1016/j.mcn.2006.08.003. Epub 2006 Sep 29. Mol Cell Neurosci. 2006. PMID: 17011208

9

NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination.

Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu M, Miller RH, Chan JR, Mi S. Lee X, et al. Among authors: pepinsky rb. J Neurosci. 2007 Jan 3;27(1):220-5. doi: 10.1523/JNEUROSCI.4175-06.2007. J Neurosci. 2007. PMID: 17202489 Free PMC article.

10

Characterization of trisulfide modification in antibodies.

Gu S, Wen D, Weinreb PH, Sun Y, Zhang L, Foley SF, Kshirsagar R, Evans D, Mi S, Meier W, Pepinsky RB. Gu S, et al. Among authors: pepinsky rb. Anal Biochem. 2010 May 1;400(1):89-98. doi: 10.1016/j.ab.2010.01.019. Epub 2010 Jan 18. Anal Biochem. 2010. PMID: 20085742

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