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Page 1
An asymmetric synthesis of (2S,5S)-5-substituted azepane-2-carboxylate derivatives.
Wishka DG, Bédard M, Brighty KE, Buzon RA, Farley KA, Fichtner MW, Kauffman GS, Kooistra J, Lewis JG, O'Dowd H, Samardjiev IJ, Samas B, Yalamanchi G, Noe MC. Wishka DG, et al. Among authors: brighty ke. J Org Chem. 2011 Mar 18;76(6):1937-40. doi: 10.1021/jo102475s. Epub 2011 Jan 28. J Org Chem. 2011. PMID: 21275376
The discovery and structure-activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: a novel potent antibacterial analog derived from hygromycin A.
Le PT, Brickner SJ, Wade SK, Brighty K, Monahan R, Stone GG, Girard D, Finegan S, Duignan J, Schafer J, Maloney M, Zaniewski RP, Connolly AG, Liras J, Bordner J, Samardjiev I. Le PT, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):276-9. doi: 10.1016/j.bmcl.2010.11.022. Epub 2010 Nov 10. Bioorg Med Chem Lett. 2011. PMID: 21115249
Synthesis and biological evaluation of novel hygromycin A antibacterial agents.
Visser MS, Freeman-Cook KD, Brickner SJ, Brighty KE, Le PT, Wade SK, Monahan R, Martinelli GJ, Blair KT, Moore DE. Visser MS, et al. Among authors: brighty ke. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6730-4. doi: 10.1016/j.bmcl.2010.08.139. Epub 2010 Sep 21. Bioorg Med Chem Lett. 2010. PMID: 20864341