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FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.
Coghill ID, Brown S, Cottle DL, McGrath MJ, Robinson PA, Nandurkar HH, Dyson JM, Mitchell CA. Coghill ID, et al. Among authors: cottle dl. J Biol Chem. 2003 Jun 27;278(26):24139-52. doi: 10.1074/jbc.M213259200. Epub 2003 Apr 18. J Biol Chem. 2003. PMID: 12704194 Free article.
FHL3 binds MyoD and negatively regulates myotube formation.
Cottle DL, McGrath MJ, Cowling BS, Coghill ID, Brown S, Mitchell CA. Cottle DL, et al. J Cell Sci. 2007 Apr 15;120(Pt 8):1423-35. doi: 10.1242/jcs.004739. Epub 2007 Mar 27. J Cell Sci. 2007. PMID: 17389685
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy.
Schessl J, Zou Y, McGrath MJ, Cowling BS, Maiti B, Chin SS, Sewry C, Battini R, Hu Y, Cottle DL, Rosenblatt M, Spruce L, Ganguly A, Kirschner J, Judkins AR, Golden JA, Goebel HH, Muntoni F, Flanigan KM, Mitchell CA, Bönnemann CG. Schessl J, et al. Among authors: cottle dl. J Clin Invest. 2008 Mar;118(3):904-12. doi: 10.1172/JCI34450. J Clin Invest. 2008. PMID: 18274675 Free PMC article.
Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer.
McGrath MJ, Binge LC, Sriratana A, Wang H, Robinson PA, Pook D, Fedele CG, Brown S, Dyson JM, Cottle DL, Cowling BS, Niranjan B, Risbridger GP, Mitchell CA. McGrath MJ, et al. Among authors: cottle dl. Cancer Res. 2013 Aug 15;73(16):5066-79. doi: 10.1158/0008-5472.CAN-12-4520. Epub 2013 Jun 25. Cancer Res. 2013. PMID: 23801747
38 results