Botrugno OA - Search Results

1

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

Di Micco R, Sulli G, Dobreva M, Liontos M, Botrugno OA, Gargiulo G, dal Zuffo R, Matti V, d'Ario G, Montani E, Mercurio C, Hahn WC, Gorgoulis V, Minucci S, d'Adda di Fagagna F. Di Micco R, et al. Among authors: botrugno oa. Nat Cell Biol. 2011 Mar;13(3):292-302. doi: 10.1038/ncb2170. Epub 2011 Feb 20. Nat Cell Biol. 2011. PMID: 21336312 Free PMC article.

2

Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer.

Botrugno OA, Santoro F, Minucci S. Botrugno OA, et al. Cancer Lett. 2009 Aug 8;280(2):134-44. doi: 10.1016/j.canlet.2009.02.027. Epub 2009 Apr 2. Cancer Lett. 2009. PMID: 19345000 Review.

3

Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy.

Botrugno OA, Robert T, Vanoli F, Foiani M, Minucci S. Botrugno OA, et al. Clin Cancer Res. 2012 May 1;18(9):2436-42. doi: 10.1158/1078-0432.CCR-11-0767. Epub 2012 Apr 18. Clin Cancer Res. 2012. PMID: 22512979

4

HDACs link the DNA damage response, processing of double-strand breaks and autophagy.

Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein KA, Rothstein R, Botrugno OA, Parazzoli D, Oldani A, Minucci S, Foiani M. Robert T, et al. Among authors: botrugno oa. Nature. 2011 Mar 3;471(7336):74-79. doi: 10.1038/nature09803. Nature. 2011. PMID: 21368826 Free PMC article.

5

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.

Santoro F, Botrugno OA, Dal Zuffo R, Pallavicini I, Matthews GM, Cluse L, Barozzi I, Senese S, Fornasari L, Moretti S, Altucci L, Pelicci PG, Chiocca S, Johnstone RW, Minucci S. Santoro F, et al. Among authors: botrugno oa. Blood. 2013 Apr 25;121(17):3459-68. doi: 10.1182/blood-2012-10-461988. Epub 2013 Feb 25. Blood. 2013. PMID: 23440245 Free article.

6

Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein.

Carbone R, Botrugno OA, Ronzoni S, Insinga A, Di Croce L, Pelicci PG, Minucci S. Carbone R, et al. Among authors: botrugno oa. Mol Cell Biol. 2006 Feb;26(4):1288-96. doi: 10.1128/MCB.26.4.1288-1296.2006. Mol Cell Biol. 2006. PMID: 16449642 Free PMC article.

7

The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia.

Soncini M, Santoro F, Gutierrez A, Frigè G, Romanenghi M, Botrugno OA, Pallavicini I, Pelicci P, Di Croce L, Minucci S. Soncini M, et al. Among authors: botrugno oa. Biochim Biophys Acta. 2013 Jan;1832(1):114-20. doi: 10.1016/j.bbadis.2012.10.001. Epub 2012 Oct 6. Biochim Biophys Acta. 2013. PMID: 23046813 Free article.

8

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Vianello P, Botrugno OA, Cappa A, Dal Zuffo R, Dessanti P, Mai A, Marrocco B, Mattevi A, Meroni G, Minucci S, Stazi G, Thaler F, Trifiró P, Valente S, Villa M, Varasi M, Mercurio C. Vianello P, et al. Among authors: botrugno oa. J Med Chem. 2016 Feb 25;59(4):1501-17. doi: 10.1021/acs.jmedchem.5b01209. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26702542

9

Immunocell-array for molecular dissection of multiple signaling pathways in mammalian cells.

Zanardi A, Giorgetti L, Botrugno OA, Minucci S, Milani P, Pelicci PG, Carbone R. Zanardi A, et al. Among authors: botrugno oa. Mol Cell Proteomics. 2007 May;6(5):939-47. doi: 10.1074/mcp.T600051-MCP200. Epub 2007 Feb 10. Mol Cell Proteomics. 2007. PMID: 17293591 Free article.

10

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Trifirò P, Cappa A, Brambillasca S, Botrugno OA, Cera MR, Zuffo RD, Dessanti P, Meroni G, Thaler F, Villa M, Minucci S, Mercurio C, Varasi M, Vianello P. Trifirò P, et al. Among authors: botrugno oa. Future Med Chem. 2017 Jul;9(11):1161-1174. doi: 10.4155/fmc-2017-0003. Epub 2017 Jul 19. Future Med Chem. 2017. PMID: 28722470

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