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Page 1
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan JH, Craighead M, Desai H, Goan KA, Ho KK, Hulskotte EG, MacSweeney CP, Milne R, Morphy JR, Neagu I, Ohlmeyer MH, Peeters AW, Presland J, Riviello C, Ruigt GS, Thomson FJ, Zanetakos HA, Zhao J, Webb ML. Napier SE, et al. Among authors: best s. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1871-5. doi: 10.1016/j.bmcl.2010.12.081. Epub 2010 Dec 21. Bioorg Med Chem Lett. 2011. PMID: 21353540
Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan R, Craighead M, Desai H, Ho KK, MacSweeney C, Milne R, Richard Morphy J, Neagu I, Ohlmeyer MH, Pick J, Presland J, Riviello C, Zanetakos HA, Zhao J, Webb ML. Napier SE, et al. Among authors: best s. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3813-7. doi: 10.1016/j.bmcl.2011.04.022. Epub 2011 Apr 13. Bioorg Med Chem Lett. 2011. PMID: 21596563
Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.
Lyons A, Kirkham J, Blades K, Orr D, Dauncey E, Smith O, Dick E, Walker R, Matthews T, Bunt A, Finlayson J, Morrison I, Savage VJ, Moyo E, Butler HS, Newman R, Ooi N, Smith A, Charrier C, Ratcliffe AJ, Stokes NR, Best S, Salisbury AM, Craighead M, Cooper IR. Lyons A, et al. Among authors: best s. Bioorg Med Chem Lett. 2022 Jun 1;65:128648. doi: 10.1016/j.bmcl.2022.128648. Epub 2022 Feb 26. Bioorg Med Chem Lett. 2022. PMID: 35231579
Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.
Cooper IR, McCarroll AJ, McGarry D, Kirkham J, Pichowicz M, Walker R, Warrilow C, Salisbury AM, Savage VJ, Moyo E, Forward H, Cheung J, Metzger R, Gault Z, Nelson G, Hughes D, Cao S, Maclean J, Charrier C, Craighead M, Best S, Stokes NR, Ratcliffe AJ. Cooper IR, et al. Among authors: best s. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4179-83. doi: 10.1016/j.bmcl.2016.07.061. Epub 2016 Jul 28. Bioorg Med Chem Lett. 2016. PMID: 27499455 Free article.
Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2.
Kirk R, Ratcliffe A, Noonan G, Uosis-Martin M, Lyth D, Bardell-Cox O, Massam J, Schofield P, Lyons A, Clare D, Maclean J, Smith A, Savage V, Mohmed S, Charrier C, Salisbury AM, Moyo E, Ooi N, Chalam-Judge N, Cheung J, Stokes NR, Best S, Craighead M, Armer R, Huxley A. Kirk R, et al. Among authors: best s. RSC Med Chem. 2020 Sep 18;11(12):1379-1385. doi: 10.1039/d0md00175a. eCollection 2020 Dec 17. RSC Med Chem. 2020. PMID: 34095845 Free PMC article.
Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1.
Kirk R, Ratcliffe A, Noonan G, Uosis-Martin M, Lyth D, Bardell-Cox O, Massam J, Schofield P, Hindley S, Jones DR, Maclean J, Smith A, Savage V, Mohmed S, Charrier C, Salisbury AM, Moyo E, Metzger R, Chalam-Judge N, Cheung J, Stokes NR, Best S, Craighead M, Armer R, Huxley A. Kirk R, et al. Among authors: best s. RSC Med Chem. 2020 Sep 18;11(12):1366-1378. doi: 10.1039/d0md00174k. eCollection 2020 Dec 17. RSC Med Chem. 2020. PMID: 34095844 Free PMC article.
Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.
Savage VJ, Charrier C, Salisbury AM, Box H, Chaffer-Malam N, Huxley A, Kirk R, Noonan GM, Mohmed S, Craighead MW, Ratcliffe AJ, Best SA, Stokes NR. Savage VJ, et al. Among authors: best sa. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5592-4. doi: 10.1128/AAC.00913-16. Print 2016 Sep. Antimicrob Agents Chemother. 2016. PMID: 27324777 Free PMC article.
Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.
Charrier C, Salisbury AM, Savage VJ, Duffy T, Moyo E, Chaffer-Malam N, Ooi N, Newman R, Cheung J, Metzger R, McGarry D, Pichowicz M, Sigerson R, Cooper IR, Nelson G, Butler HS, Craighead M, Ratcliffe AJ, Best SA, Stokes NR. Charrier C, et al. Among authors: best sa. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02100-16. doi: 10.1128/AAC.02100-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223393 Free PMC article.
Biological profiling of novel tricyclic inhibitors of bacterial DNA gyrase and topoisomerase IV.
Savage VJ, Charrier C, Salisbury AM, Moyo E, Forward H, Chaffer-Malam N, Metzger R, Huxley A, Kirk R, Uosis-Martin M, Noonan G, Mohmed S, Best SA, Ratcliffe AJ, Stokes NR. Savage VJ, et al. Among authors: best sa. J Antimicrob Chemother. 2016 Jul;71(7):1905-13. doi: 10.1093/jac/dkw061. Epub 2016 Mar 30. J Antimicrob Chemother. 2016. PMID: 27032669
Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.
Topper MJ, Guarnieri JW, Haltom JA, Chadburn A, Cope H, Frere J, An J, Borczuk A, Sinha S, Kim J, Park J, Butler D, Meydan C, Foox J, Bram Y, Richard SA, Epsi NJ, Agan B, Chenoweth JG, Simons MP, Tribble D, Burgess T, Dalgard C, Heise MT, Moorman NJ, Baxter VK, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Beigel K, Widjaja GA, Janssen KA, Lie T, Murdock DG, Angelin A, Soto Albrecht YE, Olali AZ, Cen Z, Dybas J, Priebe W, Emmett MR, Best SM, Kelsey Johnson M, Trovao NS, Clark KB, Zaksas V, Meller R, Grabham P, Schisler JC, Moraes-Vieira PM, Pollett S, Mason CE, Syrkin Wurtele E, Taylor D, Schwartz RE, Beheshti A, Wallace DC, Baylin SB. Topper MJ, et al. Among authors: best sm. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2401968121. doi: 10.1073/pnas.2401968121. Epub 2024 Nov 27. Proc Natl Acad Sci U S A. 2024. PMID: 39602262
1,012 results