Stevenson RJ - Search Results

1

Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.

Tercel M, Atwell GJ, Yang S, Ashoorzadeh A, Stevenson RJ, Botting KJ, Gu Y, Mehta SY, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: stevenson rj. Angew Chem Int Ed Engl. 2011 Mar 7;50(11):2606-9. doi: 10.1002/anie.201004456. Epub 2011 Feb 17. Angew Chem Int Ed Engl. 2011. PMID: 21370347 No abstract available.

2

Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.

Tercel M, Atwell GJ, Yang S, Stevenson RJ, Botting KJ, Boyd M, Smith E, Anderson RF, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: stevenson rj. J Med Chem. 2009 Nov 26;52(22):7258-72. doi: 10.1021/jm901202b. J Med Chem. 2009. PMID: 19877646

3

The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.

Ashoorzadeh A, Atwell GJ, Pruijn FB, Wilson WR, Tercel M, Denny WA, Stevenson RJ. Ashoorzadeh A, et al. Among authors: stevenson rj. Bioorg Med Chem. 2011 Aug 15;19(16):4851-60. doi: 10.1016/j.bmc.2011.06.073. Epub 2011 Jun 29. Bioorg Med Chem. 2011. PMID: 21767954

4

The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy.

Stevenson RJ, Denny WA, Ashoorzadeh A, Pruijn FB, van Leeuwen WF, Tercel M. Stevenson RJ, et al. Bioorg Med Chem. 2011 Oct 15;19(20):5989-98. doi: 10.1016/j.bmc.2011.08.045. Epub 2011 Aug 25. Bioorg Med Chem. 2011. PMID: 21920763

5

Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.

Stevenson RJ, Denny WA, Tercel M, Pruijn FB, Ashoorzadeh A. Stevenson RJ, et al. J Med Chem. 2012 Mar 22;55(6):2780-802. doi: 10.1021/jm201717y. Epub 2012 Mar 2. J Med Chem. 2012. PMID: 22339090

6

Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.

Milbank JB, Stevenson RJ, Ware DC, Chang JY, Tercel M, Ahn GO, Wilson WR, Denny WA. Milbank JB, et al. Among authors: stevenson rj. J Med Chem. 2009 Nov 12;52(21):6822-34. doi: 10.1021/jm9008746. J Med Chem. 2009. PMID: 19821576

7

N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs.

Lu GL, Stevenson RJ, Chang JY, Brothers PJ, Ware DC, Wilson WR, Denny WA, Tercel M. Lu GL, et al. Among authors: stevenson rj. Bioorg Med Chem. 2011 Aug 15;19(16):4861-7. doi: 10.1016/j.bmc.2011.06.076. Epub 2011 Jul 1. Bioorg Med Chem. 2011. PMID: 21775153

8

Weight loss effects of quaternary salts of 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles; structure-activity relationships.

Tercel M, Stevenson RJ, Lu GL, Stribbling SM, Wilson WR, Tatnell MA, Marnane RN, Mountjoy KG, Denny WA. Tercel M, et al. Among authors: stevenson rj. Bioorg Med Chem. 2012 Jan 15;20(2):734-49. doi: 10.1016/j.bmc.2011.12.007. Epub 2011 Dec 10. Bioorg Med Chem. 2012. PMID: 22200344

9

Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.

Chang JY, Lu GL, Stevenson RJ, Brothers PJ, Clark GR, Botting KJ, Ferry DM, Tercel M, Wilson WR, Denny WA, Ware DC. Chang JY, et al. Among authors: stevenson rj. Inorg Chem. 2013 Jul 1;52(13):7688-98. doi: 10.1021/ic4006967. Epub 2013 Jun 17. Inorg Chem. 2013. PMID: 23773210

10

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides.

Bonnet M, Hong CR, Wong WW, Liew LP, Shome A, Wang J, Gu Y, Stevenson RJ, Qi W, Anderson RF, Pruijn FB, Wilson WR, Jamieson SMF, Hicks KO, Hay MP. Bonnet M, et al. Among authors: stevenson rj. J Med Chem. 2018 Feb 8;61(3):1241-1254. doi: 10.1021/acs.jmedchem.7b01678. Epub 2018 Jan 11. J Med Chem. 2018. PMID: 29253343

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