Muthukumarana AC - Search Results

1

Functional biomarkers of musculoskeletal syndrome (MSS) for early in vivo screening of selective MMP-13 inhibitors.

Mazurek SG, Li J, Nabozny GH, Reinhart GA, Muthukumarana AC, Harrison PC, Fryer RM. Mazurek SG, et al. Among authors: muthukumarana ac. J Pharmacol Toxicol Methods. 2011 Jul-Aug;64(1):89-96. doi: 10.1016/j.vascn.2011.02.002. Epub 2011 Mar 2. J Pharmacol Toxicol Methods. 2011. PMID: 21376127

2

Mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal S6 kinase 2 inhibitors.

Fryer RM, Muthukumarana A, Chen RR, Smith JD, Mazurek SN, Harrington KE, Dinallo RM, Burke J, DiCapua FM, Guo X, Kirrane TM, Snow RJ, Zhang Y, Soleymanzadeh F, Madwed JB, Kashem MA, Kugler SZ, O'Neill MM, Harrison PC, Reinhart GA, Boyer SJ. Fryer RM, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):492-500. doi: 10.1124/jpet.111.189365. Epub 2011 Nov 29. J Pharmacol Exp Ther. 2012. PMID: 22128344

3

Strategic integration of in vivo cardiovascular models during lead optimization: predictive value of 4 models independent of species, route of administration, and influence of anesthesia.

Fryer RM, Harrison PC, Muthukumarana A, Nodop Mazurek SG, Ng KJ, Chen RR, Harrington KE, Dinallo RM, Chi L, Reinhart GA. Fryer RM, et al. J Cardiovasc Pharmacol. 2012 Apr;59(4):369-76. doi: 10.1097/FJC.0b013e31824485dd. J Cardiovasc Pharmacol. 2012. PMID: 22179024

4

The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat.

Fryer RM, Muthukumarana A, Harrison PC, Nodop Mazurek S, Chen RR, Harrington KE, Dinallo RM, Horan JC, Patnaude L, Modis LK, Reinhart GA. Fryer RM, et al. PLoS One. 2012;7(12):e52985. doi: 10.1371/journal.pone.0052985. Epub 2012 Dec 28. PLoS One. 2012. PMID: 23285242 Free PMC article.

5

CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.

Lewis ND, Muthukumarana A, Fogal SE, Corradini L, Stefanopoulos DE, Adusumalli P, Pelletier J, Panzenbeck M, Berg K, Canfield M, Cook BN, Razavi H, Kuzmich D, Anderson S, Allard D, Harrison P, Grimaldi C, Souza D, Harcken C, Fryer RM, Modis LK, Brown ML. Lewis ND, et al. PLoS One. 2014 Aug 29;9(8):e105883. doi: 10.1371/journal.pone.0105883. eCollection 2014. PLoS One. 2014. PMID: 25170619 Free PMC article.

6

G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.

Fryer RM, Ng KJ, Nodop Mazurek SG, Patnaude L, Skow DJ, Muthukumarana A, Gilpin KE, Dinallo RM, Kuzmich D, Lord J, Sanyal S, Yu H, Harcken C, Cerny MA, Hickey ER, Modis LK. Fryer RM, et al. J Pharmacol Exp Ther. 2014 Mar;348(3):421-31. doi: 10.1124/jpet.113.210005. Epub 2014 Jan 7. J Pharmacol Exp Ther. 2014. PMID: 24399854

7

Physical Properties and Effect in a Battery of Safety Pharmacology Models for Three Structurally Distinct Enteric Polymers Employed as Spray-Dried Dispersion Carriers.

Fryer RM, Patel M, Zhang X, Baum-Kroker KS, Muthukumarana A, Linehan B, Tseng YC. Fryer RM, et al. Front Pharmacol. 2016 Oct 13;7:368. doi: 10.3389/fphar.2016.00368. eCollection 2016. Front Pharmacol. 2016. PMID: 27790142 Free PMC article.

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