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Termination of STING responses is mediated via ESCRT-dependent degradation.
Balka KR, Venkatraman R, Saunders TL, Shoppee A, Pang ES, Magill Z, Homman-Ludiye J, Huang C, Lane RM, York HM, Tan P, Schittenhelm RB, Arumugam S, Kile BT, O'Keeffe M, De Nardo D. Balka KR, et al. Among authors: kile bt. EMBO J. 2023 Jun 15;42(12):e112712. doi: 10.15252/embj.2022112712. Epub 2023 May 4. EMBO J. 2023. PMID: 37139896 Free PMC article.
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Zhang JG, et al. Among authors: kile bt. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2071-6. doi: 10.1073/pnas.96.5.2071. Proc Natl Acad Sci U S A. 1999. PMID: 10051596 Free PMC article.
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Alexander WS, Starr R, Metcalf D, Nicholson SE, Farley A, Elefanty AG, Brysha M, Kile BT, Richardson R, Baca M, Zhang JG, Willson TA, Viney EM, Sprigg NS, Rakar S, Corbin J, Mifsud S, DiRago L, Cary D, Nicola NA, Hilton DJ. Alexander WS, et al. Among authors: kile bt. J Leukoc Biol. 1999 Oct;66(4):588-92. doi: 10.1002/jlb.66.4.588. J Leukoc Biol. 1999. PMID: 10534114 Review.
Functional analysis of Asb-1 using genetic modification in mice.
Kile BT, Metcalf D, Mifsud S, DiRago L, Nicola NA, Hilton DJ, Alexander WS. Kile BT, et al. Mol Cell Biol. 2001 Sep;21(18):6189-97. doi: 10.1128/MCB.21.18.6189-6197.2001. Mol Cell Biol. 2001. PMID: 11509662 Free PMC article.
The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ. Kile BT, et al. Trends Biochem Sci. 2002 May;27(5):235-41. doi: 10.1016/s0968-0004(02)02085-6. Trends Biochem Sci. 2002. PMID: 12076535 Review.
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene.
Alexander WS, Viney EM, Zhang JG, Metcalf D, Kauppi M, Hyland CD, Carpinelli MR, Stevenson W, Croker BA, Hilton AA, Ellis S, Selan C, Nandurkar HH, Goodnow CC, Kile BT, Nicola NA, Roberts AW, Hilton DJ. Alexander WS, et al. Among authors: kile bt. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16442-7. doi: 10.1073/pnas.0607872103. Epub 2006 Oct 24. Proc Natl Acad Sci U S A. 2006. PMID: 17062753 Free PMC article.
152 results