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Intercompartmental recombination of HIV-1 contributes to env intrahost diversity and modulates viral tropism and sensitivity to entry inhibitors.
Brown RJ, Peters PJ, Caron C, Gonzalez-Perez MP, Stones L, Ankghuambom C, Pondei K, McClure CP, Alemnji G, Taylor S, Sharp PM, Clapham PR, Ball JK. Brown RJ, et al. Among authors: clapham pr. J Virol. 2011 Jun;85(12):6024-37. doi: 10.1128/JVI.00131-11. Epub 2011 Apr 6. J Virol. 2011. PMID: 21471230 Free PMC article.
Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced tropism and fusigenicity for macrophages.
Peters PJ, Bhattacharya J, Hibbitts S, Dittmar MT, Simmons G, Bell J, Simmonds P, Clapham PR. Peters PJ, et al. Among authors: clapham pr. J Virol. 2004 Jul;78(13):6915-26. doi: 10.1128/JVI.78.13.6915-6926.2004. J Virol. 2004. PMID: 15194768 Free PMC article.
Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors.
Peters PJ, Duenas-Decamp MJ, Sullivan WM, Brown R, Ankghuambom C, Luzuriaga K, Robinson J, Burton DR, Bell J, Simmonds P, Ball J, Clapham PR. Peters PJ, et al. Among authors: clapham pr. Retrovirology. 2008 Jan 18;5:5. doi: 10.1186/1742-4690-5-5. Retrovirology. 2008. PMID: 18205925 Free PMC article.
139 results