Kittaka A - Search Results

1

Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor.

Sawada D, Tsukuda Y, Saito H, Kakuda S, Takimoto-Kamimura M, Ochiai E, Takenouchi K, Kittaka A. Sawada D, et al. Among authors: kittaka a. J Am Chem Soc. 2011 May 11;133(18):7215-21. doi: 10.1021/ja201481j. Epub 2011 Apr 18. J Am Chem Soc. 2011. PMID: 21500802

2

Efficient and versatile synthesis of novel 2alpha-substituted 1alpha,25-dihydroxyvitamin D(3) analogues and their docking to vitamin D receptors.

Suhara Y, Nihei KI, Kurihara M, Kittaka A, Yamaguchi K, Fujishima T, Konno K, Miyata N, Takayama H. Suhara Y, et al. Among authors: kittaka a. J Org Chem. 2001 Dec 28;66(26):8760-71. doi: 10.1021/jo010375i. J Org Chem. 2001. PMID: 11749604

3

2 alpha-(3-hydroxypropyl)- and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 accessible to vitamin D receptor mutant related to hereditary vitamin D-resistant rickets.

Kittaka A, Kurihara M, Peleg S, Suhara Y, Takayama H. Kittaka A, et al. Chem Pharm Bull (Tokyo). 2003 Mar;51(3):357-8. doi: 10.1248/cpb.51.357. Chem Pharm Bull (Tokyo). 2003. PMID: 12612432 Free article.

4

Concise synthesis and biological activities of 2alpha-alkyl- and 2alpha-(omega-hydroxyalkyl)-20-epi-1alpha,25-dihydroxyvitamin D3.

Honzawa S, Suhara Y, Nihei K, Saito N, Kishimoto S, Fujishima T, Kurihara M, Sugiura T, Waku K, Takayama H, Kittaka A. Honzawa S, et al. Among authors: kittaka a. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3503-6. doi: 10.1016/s0960-894x(03)00739-x. Bioorg Med Chem Lett. 2003. PMID: 14505658

5

Dramatic enhancement of antagonistic activity on vitamin D receptor: a double functionalization of 1alpha-hydroxyvitamin D3 26,23-lactones.

Saito N, Saito H, Anzai M, Yoshida A, Fujishima T, Takenouchi K, Miura D, Ishizuka S, Takayama H, Kittaka A. Saito N, et al. Among authors: kittaka a. Org Lett. 2003 Dec 11;5(25):4859-62. doi: 10.1021/ol035922w. Org Lett. 2003. PMID: 14653692

6

Remarkable effect of 2[small alpha]-modification on the VDR antagonistic activity of 1small alpha-hydroxyvitamin D3-26,23-lactones.

Saito N, Matsunaga T, Fujishima T, Anzai M, Saito H, Takenouchi K, Miura D, Ishizuka S, Takayama H, Kittaka A. Saito N, et al. Among authors: kittaka a. Org Biomol Chem. 2003 Dec 21;1(24):4396-402. doi: 10.1039/b311107e. Epub 2003 Nov 6. Org Biomol Chem. 2003. PMID: 14685312

7

Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D3 Analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity.

Saito N, Suhara Y, Kurihara M, Fujishima T, Honzawa S, Takayanagi H, Kozono T, Matsumoto M, Ohmori M, Miyata N, Takayama H, Kittaka A. Saito N, et al. Among authors: kittaka a. J Org Chem. 2004 Oct 29;69(22):7463-71. doi: 10.1021/jo0491051. J Org Chem. 2004. PMID: 15497970

8

Recent results on A-ring modification of 1alpha,25-dihydroxyvitamin D3: design and synthesis of VDR-agonists and antagonists with high biological activity.

Saito N, Honzawa S, Kittaka A. Saito N, et al. Among authors: kittaka a. Curr Top Med Chem. 2006;6(12):1273-88. doi: 10.2174/156802606777864953. Curr Top Med Chem. 2006. PMID: 16848741

9

Highly potent vitamin D receptor antagonists: design, synthesis, and biological evaluation.

Saito N, Kittaka A. Saito N, et al. Among authors: kittaka a. Chembiochem. 2006 Oct;7(10):1479-90. doi: 10.1002/cbic.200600054. Chembiochem. 2006. PMID: 16871612

10

Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones.

Saito N, Matsunaga T, Saito H, Anzai M, Takenouchi K, Miura D, Namekawa J, Ishizuka S, Kittaka A. Saito N, et al. Among authors: kittaka a. J Med Chem. 2006 Nov 30;49(24):7063-75. doi: 10.1021/jm060797q. J Med Chem. 2006. PMID: 17125259

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