Cohen GM - Search Results

1

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

Vogler M, Dickens D, Dyer MJ, Owen A, Pirmohamed M, Cohen GM. Vogler M, et al. Among authors: cohen gm. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. doi: 10.1016/j.bbrc.2011.04.043. Epub 2011 Apr 13. Biochem Biophys Res Commun. 2011. PMID: 21514278

2

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.

Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Vogler M, et al. Among authors: cohen gm. Blood. 2009 Apr 30;113(18):4403-13. doi: 10.1182/blood-2008-08-173310. Epub 2008 Nov 13. Blood. 2009. PMID: 19008458 Free article.

3

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM. Vogler M, et al. Among authors: cohen gm. Clin Cancer Res. 2010 Aug 15;16(16):4217-25. doi: 10.1158/1078-0432.CCR-10-0777. Epub 2010 Jul 2. Clin Cancer Res. 2010. PMID: 20601444 Free PMC article.

4

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM. Vogler M, et al. Among authors: cohen gm. Blood. 2011 Jun 30;117(26):7145-54. doi: 10.1182/blood-2011-03-344812. Epub 2011 May 11. Blood. 2011. PMID: 21562047 Free article.

5

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM. Vogler M, et al. Among authors: cohen gm. Br J Haematol. 2013 Oct;163(1):139-42. doi: 10.1111/bjh.12457. Epub 2013 Jul 4. Br J Haematol. 2013. PMID: 23826785 Free article. No abstract available.

6

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.

Vogler M, Dinsdale D, Sun XM, Young KW, Butterworth M, Nicotera P, Dyer MJ, Cohen GM. Vogler M, et al. Among authors: cohen gm. Cell Death Differ. 2008 May;15(5):820-30. doi: 10.1038/cdd.2008.25. Epub 2008 Feb 29. Cell Death Differ. 2008. PMID: 18309326

7

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM. Vogler M, et al. Among authors: cohen gm. Cell Death Differ. 2009 Mar;16(3):360-7. doi: 10.1038/cdd.2008.137. Epub 2008 Sep 19. Cell Death Differ. 2009. PMID: 18806758 Review.

8

Different forms of cell death induced by putative BCL2 inhibitors.

Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ, Cohen GM. Vogler M, et al. Among authors: cohen gm. Cell Death Differ. 2009 Jul;16(7):1030-9. doi: 10.1038/cdd.2009.48. Epub 2009 Apr 24. Cell Death Differ. 2009. PMID: 19390557

9

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

Dewson G, Snowden RT, Almond JB, Dyer MJ, Cohen GM. Dewson G, et al. Among authors: cohen gm. Oncogene. 2003 May 1;22(17):2643-54. doi: 10.1038/sj.onc.1206326. Oncogene. 2003. PMID: 12730678

10

Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

Inoue S, Mai A, Dyer MJ, Cohen GM. Inoue S, et al. Among authors: cohen gm. Cancer Res. 2006 Jul 1;66(13):6785-92. doi: 10.1158/0008-5472.CAN-05-4563. Cancer Res. 2006. PMID: 16818655

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