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106 results

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Page 1
Optimisation of a novel series of selective CNS penetrant CB(2) agonists.
Watson C, Owen DR, Harding D, Kon-I K, Lewis ML, Mason HJ, Matsumizu M, Mukaiyama T, Rodriguez-Lens M, Shima A, Takeuchi M, Tran I, Young T. Watson C, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4284-7. doi: 10.1016/j.bmcl.2011.05.063. Epub 2011 May 25. Bioorg Med Chem Lett. 2011. PMID: 21669533
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
Glossop PA, Watson CA, Price DA, Bunnage ME, Middleton DS, Wood A, James K, Roberts D, Strang RS, Yeadon M, Perros-Huguet C, Clarke NP, Trevethick MA, Machin I, Stuart EF, Evans SM, Harrison AC, Fairman DA, Agoram B, Burrows JL, Feeder N, Fulton CK, Dillon BR, Entwistle DA, Spence FJ. Glossop PA, et al. Among authors: watson ca. J Med Chem. 2011 Oct 13;54(19):6888-904. doi: 10.1021/jm200884j. Epub 2011 Sep 20. J Med Chem. 2011. PMID: 21870878 Clinical Trial.
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).
Owen RM, Blakemore D, Cao L, Flanagan N, Fish R, Gibson KR, Gurrell R, Huh CW, Kammonen J, Mortimer-Cassen E, Nickolls SA, Omoto K, Owen D, Pike A, Pryde DC, Reynolds DS, Roeloffs R, Rose C, Stead C, Takeuchi M, Warmus JS, Watson C. Owen RM, et al. J Med Chem. 2019 Jun 27;62(12):5773-5796. doi: 10.1021/acs.jmedchem.9b00322. Epub 2019 Apr 26. J Med Chem. 2019. PMID: 30964988
Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.
Nickolls SA, Gurrell R, van Amerongen G, Kammonen J, Cao L, Brown AR, Stead C, Mead A, Watson C, Hsu C, Owen RM, Pike A, Fish RL, Chen L, Qiu R, Morris ED, Feng G, Whitlock M, Gorman D, van Gerven J, Reynolds DS, Dua P, Butt RP. Nickolls SA, et al. Br J Pharmacol. 2018 Feb;175(4):708-725. doi: 10.1111/bph.14119. Epub 2018 Jan 18. Br J Pharmacol. 2018. PMID: 29214652 Free PMC article. Clinical Trial.
Crop rotational diversity can mitigate climate-induced grain yield losses.
Costa A, Bommarco R, Smith ME, Bowles T, Gaudin ACM, Watson CA, Alarcón R, Berti A, Blecharczyk A, Calderon FJ, Culman S, Deen W, Drury CF, Garcia Y Garcia A, García-Díaz A, Hernández Plaza E, Jonczyk K, Jäck O, Navarrete Martínez L, Montemurro F, Morari F, Onofri A, Osborne SL, Tenorio Pasamón JL, Sandström B, Santín-Montanyá I, Sawinska Z, Schmer MR, Stalenga J, Strock J, Tei F, Topp CFE, Ventrella D, Walker RL, Vico G. Costa A, et al. Among authors: watson ca. Glob Chang Biol. 2024 May;30(5):e17298. doi: 10.1111/gcb.17298. Glob Chang Biol. 2024. PMID: 38712640
COVID-19 impacts equine welfare: Policy implications for laminitis and obesity.
Ward AB, Stephen K, Argo CM, Harris PA, Watson CA, Neacsu M, Russell W, Grove-White DH, Morrison PK. Ward AB, et al. Among authors: watson ca. PLoS One. 2021 May 28;16(5):e0252340. doi: 10.1371/journal.pone.0252340. eCollection 2021. PLoS One. 2021. PMID: 34048478 Free PMC article.
106 results