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Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Dikalova A, Aschner JL, Kaplowitz MR, Summar M, Fike CD. Dikalova A, et al. Among authors: aschner jl. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L743-L753. doi: 10.1152/ajplung.00238.2016. Epub 2016 Aug 19. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27542807 Free PMC article.
We previously showed that newborn piglets who develop pulmonary hypertension during exposure to chronic hypoxia have diminished pulmonary vascular nitric oxide (NO) production and evidence of endothelial NO synthase (eNOS) uncoupling (Fike CD, Dikalova A, Kaplowitz MR, Cunningham …
We previously showed that newborn piglets who develop pulmonary hypertension during exposure to chronic hypoxia have diminished pulmonary va …
Combined l-citrulline and tetrahydrobiopterin therapy improves NO signaling and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.
Dikalova A, Aschner JL, Kaplowitz MR, Cunningham G, Summar M, Fike CD. Dikalova A, et al. Among authors: aschner jl. Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L762-L772. doi: 10.1152/ajplung.00280.2019. Epub 2020 Feb 19. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32073878 Free PMC article.
165 results