Xiao H - Search Results

1

Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.

Bhaumik P, Horimoto Y, Xiao H, Miura T, Hidaka K, Kiso Y, Wlodawer A, Yada RY, Gustchina A. Bhaumik P, et al. Among authors: xiao h. J Struct Biol. 2011 Jul;175(1):73-84. doi: 10.1016/j.jsb.2011.04.009. Epub 2011 Apr 20. J Struct Biol. 2011. PMID: 21521654 Free PMC article.

2

Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.

Bhaumik P, Xiao H, Parr CL, Kiso Y, Gustchina A, Yada RY, Wlodawer A. Bhaumik P, et al. Among authors: xiao h. J Mol Biol. 2009 May 8;388(3):520-40. doi: 10.1016/j.jmb.2009.03.011. Epub 2009 Mar 11. J Mol Biol. 2009. PMID: 19285084 Free PMC article.

3

Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum.

Bhaumik P, Xiao H, Hidaka K, Gustchina A, Kiso Y, Yada RY, Wlodawer A. Bhaumik P, et al. Among authors: xiao h. Biochemistry. 2011 Oct 18;50(41):8862-79. doi: 10.1021/bi201118z. Epub 2011 Sep 26. Biochemistry. 2011. PMID: 21928835 Free PMC article.

4

The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active.

Xiao H, Bryksa BC, Bhaumik P, Gustchina A, Kiso Y, Yao SQ, Wlodawer A, Yada RY. Xiao H, et al. Mol Biochem Parasitol. 2014 Oct;197(1-2):56-63. doi: 10.1016/j.molbiopara.2014.10.004. Epub 2014 Oct 25. Mol Biochem Parasitol. 2014. PMID: 25447707 Free PMC article.

5

Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights.

Mishra V, Rathore I, Arekar A, Sthanam LK, Xiao H, Kiso Y, Sen S, Patankar S, Gustchina A, Hidaka K, Wlodawer A, Yada RY, Bhaumik P. Mishra V, et al. Among authors: xiao h. FEBS J. 2018 Aug;285(16):3077-3096. doi: 10.1111/febs.14598. Epub 2018 Jul 7. FEBS J. 2018. PMID: 29943906 Free PMC article.

6

Activation mechanism of plasmepsins, pepsin-like aspartic proteases from Plasmodium, follows a unique trans-activation pathway.

Rathore I, Mishra V, Patel C, Xiao H, Gustchina A, Wlodawer A, Yada RY, Bhaumik P. Rathore I, et al. Among authors: xiao h. FEBS J. 2021 Jan;288(2):678-698. doi: 10.1111/febs.15363. Epub 2020 May 26. FEBS J. 2021. PMID: 32385863 Free PMC article.

7

Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme.

Kesari P, Deshmukh A, Pahelkar N, Suryawanshi AB, Rathore I, Mishra V, Dupuis JH, Xiao H, Gustchina A, Abendroth J, Labaied M, Yada RY, Wlodawer A, Edwards TE, Lorimer DD, Bhaumik P. Kesari P, et al. Among authors: xiao h. Protein Sci. 2022 Apr;31(4):882-899. doi: 10.1002/pro.4279. Epub 2022 Feb 5. Protein Sci. 2022. PMID: 35048450 Free PMC article.

8

Expression and enzymatic characterization of the soluble recombinant plasmepsin I from Plasmodium falciparum.

Xiao H, Tanaka T, Ogawa M, Yada RY. Xiao H, et al. Protein Eng Des Sel. 2007 Dec;20(12):625-33. doi: 10.1093/protein/gzm066. Epub 2007 Dec 10. Protein Eng Des Sel. 2007. PMID: 18073224

9

The native conformation of plasmepsin II is kinetically trapped at neutral pH.

Xiao H, Dee D, Yada RY. Xiao H, et al. Arch Biochem Biophys. 2011 Sep 15;513(2):102-9. doi: 10.1016/j.abb.2011.06.017. Epub 2011 Jul 13. Arch Biochem Biophys. 2011. PMID: 21767524

10

The prosegment catalyzes native folding of Plasmodium falciparum plasmepsin II.

Jaafar AH, Xiao H, Dee DR, Bryksa BC, Bhaumik P, Yada RY. Jaafar AH, et al. Among authors: xiao h. Biochim Biophys Acta. 2016 Oct;1864(10):1356-62. doi: 10.1016/j.bbapap.2016.06.019. Epub 2016 Jul 1. Biochim Biophys Acta. 2016. PMID: 27378574

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