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The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.
Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR. Kumar N, et al. Among authors: solt la. Mol Pharmacol. 2010 Feb;77(2):228-36. doi: 10.1124/mol.109.060905. Epub 2009 Nov 3. Mol Pharmacol. 2010. PMID: 19887649 Free PMC article.
Regulation of adipogenesis by natural and synthetic REV-ERB ligands.
Kumar N, Solt LA, Wang Y, Rogers PM, Bhattacharyya G, Kamenecka TM, Stayrook KR, Crumbley C, Floyd ZE, Gimble JM, Griffin PR, Burris TP. Kumar N, et al. Among authors: solt la. Endocrinology. 2010 Jul;151(7):3015-25. doi: 10.1210/en.2009-0800. Epub 2010 Apr 28. Endocrinology. 2010. PMID: 20427485 Free PMC article.
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist.
Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Kumar N, et al. Among authors: solt la. ACS Chem Biol. 2011 Mar 18;6(3):218-22. doi: 10.1021/cb1002762. Epub 2010 Dec 6. ACS Chem Biol. 2011. PMID: 21090593 Free PMC article.
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidović D, Schürer SC, Xu J, Wagoner G, Drew PD, Griffin PR, Burris TP. Solt LA, et al. Nature. 2011 Apr 28;472(7344):491-4. doi: 10.1038/nature10075. Epub 2011 Apr 17. Nature. 2011. PMID: 21499262 Free PMC article.
Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis.
Begriche K, Levasseur PR, Zhang J, Rossi J, Skorupa D, Solt LA, Young B, Burris TP, Marks DL, Mynatt RL, Butler AA. Begriche K, et al. Among authors: solt la. J Biol Chem. 2011 Nov 25;286(47):40771-81. doi: 10.1074/jbc.M111.278374. Epub 2011 Oct 7. J Biol Chem. 2011. PMID: 21984834 Free PMC article.
69 results