Cumming JG - Search Results

1

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.

De Savi C, Pape A, Sawyer Y, Milne D, Davies C, Cumming JG, Ting A, Lamont S, Smith PD, Tart J, Page K, Moore P. De Savi C, et al. Among authors: cumming jg. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. doi: 10.1016/j.bmcl.2011.04.028. Epub 2011 Apr 13. Bioorg Med Chem Lett. 2011. PMID: 21536437

2

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.

De Savi C, Pape A, Cumming JG, Ting A, Smith PD, Burrows JN, Mills M, Davies C, Lamont S, Milne D, Cook C, Moore P, Sawyer Y, Gerhardt S. De Savi C, et al. Among authors: cumming jg. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1376-81. doi: 10.1016/j.bmcl.2011.01.036. Epub 2011 Jan 18. Bioorg Med Chem Lett. 2011. PMID: 21300546

3

Discovery and characterization of MAPK-activated protein kinase-2 prevention of activation inhibitors.

Cumming JG, Debreczeni JÉ, Edfeldt F, Evertsson E, Harrison M, Holdgate GA, James MJ, Lamont SG, Oldham K, Sullivan JE, Wells SL. Cumming JG, et al. J Med Chem. 2015 Jan 8;58(1):278-93. doi: 10.1021/jm501038s. Epub 2014 Oct 9. J Med Chem. 2015. PMID: 25255283

4

Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase.

Cumming JG, McKenzie CL, Bowden SG, Campbell D, Masters DJ, Breed J, Jewsbury PJ. Cumming JG, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5389-94. doi: 10.1016/j.bmcl.2004.08.007. Bioorg Med Chem Lett. 2004. PMID: 15454232

5

Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.

Cumming JG, Tucker H, Oldfield J, Fielding C, Highton A, Faull A, Wild M, Brown D, Wells S, Shaw J. Cumming JG, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1655-9. doi: 10.1016/j.bmcl.2011.12.117. Epub 2012 Jan 2. Bioorg Med Chem Lett. 2012. PMID: 22266038

6

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.

Brown DS, Cumming JG, Bethel P, Finlayson J, Gerhardt S, Nash I, Pauptit RA, Pike KG, Reid A, Snelson W, Swallow S, Thompson C. Brown DS, et al. Among authors: cumming jg. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. doi: 10.1016/j.bmcl.2012.04.116. Epub 2012 May 2. Bioorg Med Chem Lett. 2012. PMID: 22608965

7

Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.

Cumming JG, Brown SJ, Cooper AE, Faull AW, Flynn AP, Grime K, Oldfield J, Shaw JS, Shepherd E, Tucker H, Whittaker D. Cumming JG, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3533-6. doi: 10.1016/j.bmcl.2006.03.089. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16631366

8

Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides.

Cumming JG, Cooper AE, Grime K, Logan CJ, McLaughlin S, Oldfield J, Shaw JS, Tucker H, Winter J, Whittaker D. Cumming JG, et al. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5012-5. doi: 10.1016/j.bmcl.2005.08.014. Bioorg Med Chem Lett. 2005. PMID: 16154744

9

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

Burrows JN, Cumming JG, Fillery SM, Hamlin GA, Hudson JA, Jackson RJ, McLaughlin S, Shaw JS. Burrows JN, et al. Among authors: cumming jg. Bioorg Med Chem Lett. 2005 Jan 3;15(1):25-8. doi: 10.1016/j.bmcl.2004.10.044. Bioorg Med Chem Lett. 2005. PMID: 15582404

10

The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity.

Cumming JG, Bower JF, Waterson D, Faull A, Poyser PJ, Turner P, McDermott B, Campbell AD, Hudson J, James M, Winter J, Wood C. Cumming JG, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3895-9. doi: 10.1016/j.bmcl.2012.04.118. Epub 2012 May 2. Bioorg Med Chem Lett. 2012. PMID: 22608963

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