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Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival.
Peng Q, Nowocin A, Ratnasothy K, Smith RA, Smyth LA, Lechler RI, Dorling A, Lombardi G. Peng Q, et al. Among authors: smyth la. Front Immunol. 2023 Jan 30;13:980462. doi: 10.3389/fimmu.2022.980462. eCollection 2022. Front Immunol. 2023. PMID: 36793549 Free PMC article.
Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment.
Jacob J, Nadkarni S, Volpe A, Peng Q, Tung SL, Hannen RF, Mohseni YR, Scotta C, Marelli-Berg FM, Lechler RI, Smyth LA, Fruhwirth GO, Lombardi G. Jacob J, et al. Among authors: smyth la. Mol Ther Methods Clin Dev. 2020 Dec 10;20:324-336. doi: 10.1016/j.omtm.2020.12.003. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33511246 Free PMC article.
Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage.
Tung SL, Fanelli G, Matthews RI, Bazoer J, Letizia M, Vizcay-Barrena G, Faruqu FN, Philippeos C, Hannen R, Al-Jamal KT, Lombardi G, Smyth LA. Tung SL, et al. Among authors: smyth la. Front Cell Dev Biol. 2020 May 20;8:317. doi: 10.3389/fcell.2020.00317. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32509778 Free PMC article.
51 results