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Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.
Bish LT, Sleeper MM, Reynolds C, Gazzara J, Withnall E, Singletary GE, Buchlis G, Hui D, High KA, Gao G, Wilson JM, Sweeney HL. Bish LT, et al. Among authors: sleeper mm. Hum Gene Ther. 2011 Aug;22(8):969-77. doi: 10.1089/hum.2011.035. Epub 2011 Jun 8. Hum Gene Ther. 2011. PMID: 21542669 Free PMC article.
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