Lynch JA - Search Results

1

IDH1 and IDH2 mutations in pediatric acute leukemia.

Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR. Andersson AK, et al. Among authors: lynch ja. Leukemia. 2011 Oct;25(10):1570-7. doi: 10.1038/leu.2011.133. Epub 2011 Jun 7. Leukemia. 2011. PMID: 21647154 Free PMC article.

2

Cell survival under stress is enhanced by a mitochondrial ATP-binding cassette transporter that regulates hemoproteins.

Lynch J, Fukuda Y, Krishnamurthy P, Du G, Schuetz JD. Lynch J, et al. Cancer Res. 2009 Jul 1;69(13):5560-7. doi: 10.1158/0008-5472.CAN-09-0078. Epub 2009 Jun 23. Cancer Res. 2009. PMID: 19549895 Free PMC article.

3

ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

Ulrich DL, Lynch J, Wang Y, Fukuda Y, Nachagari D, Du G, Sun D, Fan Y, Tsurkan L, Potter PM, Rehg JE, Schuetz JD. Ulrich DL, et al. J Biol Chem. 2012 Apr 13;287(16):12679-90. doi: 10.1074/jbc.M111.336180. Epub 2012 Jan 31. J Biol Chem. 2012. PMID: 22294697 Free PMC article.

4

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.

Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Perciavalle RM, et al. Nat Cell Biol. 2012 Apr 29;14(6):575-83. doi: 10.1038/ncb2488. Nat Cell Biol. 2012. PMID: 22544066 Free PMC article.

5

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.

Wang X, Bathina M, Lynch J, Koss B, Calabrese C, Frase S, Schuetz JD, Rehg JE, Opferman JT. Wang X, et al. Genes Dev. 2013 Jun 15;27(12):1351-64. doi: 10.1101/gad.215855.113. Genes Dev. 2013. PMID: 23788622 Free PMC article.

6

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Li-Harms X, Milasta S, Lynch J, Wright C, Joshi A, Iyengar R, Neale G, Wang X, Wang YD, Prolla TA, Thompson JE, Opferman JT, Green DR, Schuetz J, Kundu M. Li-Harms X, et al. Blood. 2015 Jan 1;125(1):162-74. doi: 10.1182/blood-2014-07-586396. Epub 2014 Nov 19. Blood. 2015. PMID: 25411424 Free PMC article.

7

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

Morgan JA, Lynch J, Panetta JC, Wang Y, Frase S, Bao J, Zheng J, Opferman JT, Janke L, Green DM, Chemaitilly W, Schuetz JD. Morgan JA, et al. Among authors: lynch j. Sci Rep. 2015 Nov 18;5:16488. doi: 10.1038/srep16488. Sci Rep. 2015. PMID: 26576726 Free PMC article.

8

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.

Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD. Fukuda Y, et al. Nat Commun. 2016 Aug 10;7:12353. doi: 10.1038/ncomms12353. Nat Commun. 2016. PMID: 27507172 Free PMC article.

9

Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD. Fukuda Y, et al. JCI Insight. 2017 Aug 3;2(15):e92409. doi: 10.1172/jci.insight.92409. eCollection 2017 Aug 3. JCI Insight. 2017. PMID: 28768907 Free PMC article.

10

ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket.

Gose T, Shafi T, Fukuda Y, Das S, Wang Y, Allcock A, Gavan McHarg A, Lynch J, Chen T, Tamai I, Shelat A, Ford RC, Schuetz JD. Gose T, et al. FASEB J. 2020 Apr;34(4):4890-4903. doi: 10.1096/fj.201902338RR. Epub 2020 Feb 17. FASEB J. 2020. PMID: 32067270 Free PMC article.

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