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Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.
Int J Chron Obstruct Pulmon Dis. 2011;6:209-17. doi: 10.2147/COPD.S15922. Epub 2011 Mar 13.
Int J Chron Obstruct Pulmon Dis. 2011.
PMID: 21660298
Free PMC article.
An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.
Pastukh V, Roberts JT, Clark DW, Bardwell GC, Patel M, Al-Mehdi AB, Borchert GM, Gillespie MN.
Pastukh V, et al. Among authors: bardwell gc.
Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1367-75. doi: 10.1152/ajplung.00236.2015. Epub 2015 Oct 2.
Am J Physiol Lung Cell Mol Physiol. 2015.
PMID: 26432868
Free PMC article.
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Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription.
Al-Mehdi AB, Pastukh VM, Swiger BM, Reed DJ, Patel MR, Bardwell GC, Pastukh VV, Alexeyev MF, Gillespie MN.
Al-Mehdi AB, et al. Among authors: bardwell gc.
Sci Signal. 2012 Jul 3;5(231):ra47. doi: 10.1126/scisignal.2002712.
Sci Signal. 2012.
PMID: 22763339
Free PMC article.
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