Evans DC - Search Results

1

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Chem Res Toxicol. 2011 Jul 18;24(7):1012-30. doi: 10.1021/tx1004437. Epub 2011 Jun 28. Chem Res Toxicol. 2011. PMID: 21667953

2

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.

Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Rapid Commun Mass Spectrom. 2008 Apr;22(8):1295-311. doi: 10.1002/rcm.3504. Rapid Commun Mass Spectrom. 2008. PMID: 18383206

3

LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume.

Xu Y, Yuan Y, Smith L, Edom R, Weng N, Mamidi R, Silva J, Evans DC, Lim HK. Xu Y, et al. Among authors: evans dc. J Pharm Biomed Anal. 2013 Nov;85:145-54. doi: 10.1016/j.jpba.2013.07.016. Epub 2013 Jul 25. J Pharm Biomed Anal. 2013. PMID: 23948760

4

Free radical metabolism of raloxifene in human liver microsomes.

Lim HK, Yang M, Lam W, Xu F, Chen J, Xu Y, Shetty HU, Yang K, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Xenobiotica. 2012 Aug;42(8):737-47. doi: 10.3109/00498254.2012.662306. Xenobiotica. 2012. PMID: 22375838

5

A nonradioactive approach to investigate the metabolism of therapeutic peptides by tagging with 127i and using inductively-coupled plasma mass spectrometry analysis.

Lim HK, Cao Y, Qiu X, Silva J, Evans DC. Lim HK, et al. Among authors: evans dc. Drug Metab Dispos. 2015 Jan;43(1):17-26. doi: 10.1124/dmd.114.059774. Epub 2014 Oct 14. Drug Metab Dispos. 2015. PMID: 25315343

6

In vitro bioactivation of dihydrobenzoxathiin selective estrogen receptor modulators by cytochrome P450 3A4 in human liver microsomes: formation of reactive iminium and quinone type metabolites.

Zhang Z, Chen Q, Li Y, Doss GA, Dean BJ, Ngui JS, Silva Elipe M, Kim S, Wu JY, Dininno F, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Zhang Z, et al. Among authors: evans dc. Chem Res Toxicol. 2005 Apr;18(4):675-85. doi: 10.1021/tx0496789. Chem Res Toxicol. 2005. PMID: 15833027

7

Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.

Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA. Evans DC, et al. Chem Res Toxicol. 2004 Jan;17(1):3-16. doi: 10.1021/tx034170b. Chem Res Toxicol. 2004. PMID: 14727914 Review.

8

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC. Leclercq L, et al. Among authors: evans dc. Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Chem Res Toxicol. 2009. PMID: 19183054 Review.

9

Metabolic activation of a 1,3-disubstituted piperazine derivative: evidence for a novel ring contraction to an imidazoline.

Doss GA, Miller RR, Zhang Z, Teffera Y, Nargund RP, Palucki B, Park MK, Tang YS, Evans DC, Baillie TA, Stearns RA. Doss GA, et al. Among authors: evans dc. Chem Res Toxicol. 2005 Feb;18(2):271-6. doi: 10.1021/tx049711r. Chem Res Toxicol. 2005. PMID: 15720132

10

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.

Chen Q, Ngui JS, Doss GA, Wang RW, Cai X, DiNinno FP, Blizzard TA, Hammond ML, Stearns RA, Evans DC, Baillie TA, Tang W. Chen Q, et al. Among authors: evans dc. Chem Res Toxicol. 2002 Jul;15(7):907-14. doi: 10.1021/tx0200109. Chem Res Toxicol. 2002. PMID: 12119000

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