Yang SC - Search Results

1

Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents.

Yang X, Shi Q, Yang SC, Chen CY, Yu SL, Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH. Yang X, et al. Among authors: yang pc, yang sc. J Med Chem. 2011 Jul 28;54(14):5097-107. doi: 10.1021/jm200330s. Epub 2011 Jun 28. J Med Chem. 2011. PMID: 21668000 Free PMC article.

2

Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha.

Wu CC, Lin JC, Yang SC, Lin CW, Chen JJ, Shih JY, Hong TM, Yang PC. Wu CC, et al. Among authors: yang pc, yang sc. Mol Cancer Ther. 2008 Jun;7(6):1365-75. doi: 10.1158/1535-7163.MCT-08-0091. Epub 2008 Jun 4. Mol Cancer Ther. 2008. PMID: 18524846

3

Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma.

Chao YC, Pan SH, Yang SC, Yu SL, Che TF, Lin CW, Tsai MS, Chang GC, Wu CH, Wu YY, Lee YC, Hong TM, Yang PC. Chao YC, et al. Among authors: yang pc, yang sc. Am J Respir Crit Care Med. 2009 Jan 15;179(2):123-33. doi: 10.1164/rccm.200803-456OC. Epub 2008 Sep 11. Am J Respir Crit Care Med. 2009. PMID: 18787218

4

Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways.

Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH. Lin JC, et al. Among authors: yang pc, yang sc. J Med Chem. 2009 Apr 9;52(7):1903-11. doi: 10.1021/jm801344j. J Med Chem. 2009. PMID: 19284764 Free PMC article.

5

Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents.

Yang X, Shi Q, Liu YN, Zhao G, Bastow KF, Lin JC, Yang SC, Yang PC, Lee KH. Yang X, et al. Among authors: yang pc, yang sc. J Med Chem. 2009 Aug 27;52(16):5262-8. doi: 10.1021/jm9009263. J Med Chem. 2009. PMID: 19645447 Free PMC article.

6

Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action.

Nakagawa-Goto K, Wu PC, Bastow KF, Yang SC, Yu SL, Chen HY, Lin JC, Goto M, Morris-Natschke SL, Yang PC, Lee KH. Nakagawa-Goto K, et al. Among authors: yang pc, yang sc. Bioorg Med Chem. 2011 Mar 1;19(5):1816-22. doi: 10.1016/j.bmc.2011.01.001. Epub 2011 Jan 15. Bioorg Med Chem. 2011. PMID: 21296579 Free PMC article.

7

Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.

Yang X, Shi Q, Lai CY, Chen CY, Ohkoshi E, Yang SC, Wang CY, Bastow KF, Wu TS, Pan SL, Teng CM, Yang PC, Lee KH. Yang X, et al. Among authors: yang pc, yang sc. J Med Chem. 2012 Aug 9;55(15):6751-61. doi: 10.1021/jm3001218. Epub 2012 Jul 23. J Med Chem. 2012. PMID: 22823514 Free PMC article.

8

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.

Lin CW, Chang YL, Chang YC, Lin JC, Chen CC, Pan SH, Wu CT, Chen HY, Yang SC, Hong TM, Yang PC. Lin CW, et al. Among authors: yang pc, yang sc. Nat Commun. 2013;4:1877. doi: 10.1038/ncomms2876. Nat Commun. 2013. PMID: 23695671 Free article.

9

Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation.

Chen CY, Jan CI, Lo JF, Yang SC, Chang YL, Pan SH, Wang WL, Hong TM, Yang PC. Chen CY, et al. Among authors: yang pc, yang sc. Cancer Res. 2013 Jul 1;73(13):4009-19. doi: 10.1158/0008-5472.CAN-12-4066. Epub 2013 May 22. Cancer Res. 2013. PMID: 23698466

10

The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.

Chen CY, Yang SC, Lee KH, Yang X, Wei LY, Chow LP, Wang TC, Hong TM, Lin JC, Kuan C, Yang PC. Chen CY, et al. Among authors: yang pc, yang sc, yang x. J Med Chem. 2014 Feb 13;57(3):677-85. doi: 10.1021/jm401686b. Epub 2014 Jan 31. J Med Chem. 2014. PMID: 24428777 Free PMC article.

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