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Page 1
The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.
Abbas A, Imrie H, Viswambharan H, Sukumar P, Rajwani A, Cubbon RM, Gage M, Smith J, Galloway S, Yuldeshava N, Kahn M, Xuan S, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT. Abbas A, et al. Among authors: galloway s. Diabetes. 2011 Aug;60(8):2169-78. doi: 10.2337/db11-0197. Epub 2011 Jun 15. Diabetes. 2011. PMID: 21677284 Free PMC article.
Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype.
Yuldasheva NY, Rashid ST, Haywood NJ, Cordell P, Mughal R, Viswambharan H, Imrie H, Sukumar P, Cubbon RM, Aziz A, Gage M, Mbonye KA, Smith J, Galloway S, Skromna A, Scott DJ, Kearney MT, Wheatcroft SB. Yuldasheva NY, et al. Among authors: galloway s. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2051-8. doi: 10.1161/ATVBAHA.114.304121. Epub 2014 Jul 10. Arterioscler Thromb Vasc Biol. 2014. PMID: 25012136
Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.
Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood N, Walker AM, Skromna A, Makova N, Galloway S, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft SB, Cubbon RM, Kearney MT. Viswambharan H, et al. Among authors: galloway s. Circ Res. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5. Circ Res. 2017. PMID: 27920123 Free article.
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.
Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AMN, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM. Watt NT, et al. Among authors: galloway s. Diabetes. 2017 Nov;66(11):2808-2821. doi: 10.2337/db17-0062. Epub 2017 Aug 22. Diabetes. 2017. PMID: 28830894 Free article.
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.
Sengupta A, Patel PA, Yuldasheva NY, Mughal RS, Galloway S, Viswambharan H, Walker AMN, Aziz A, Smith J, Ali N, Mercer BN, Imrie H, Sukumar P, Wheatcroft SB, Kearney MT, Cubbon RM. Sengupta A, et al. Among authors: galloway s. Endocrinology. 2018 Aug 1;159(8):2917-2925. doi: 10.1210/en.2018-00215. Endocrinology. 2018. PMID: 29796592 Free PMC article.
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Imrie H, Viswambharan H, Sukumar P, Abbas A, Cubbon RM, Yuldasheva N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers TS, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT. Imrie H, et al. Among authors: galloway s. Diabetes. 2012 Sep;61(9):2359-68. doi: 10.2337/db11-1494. Epub 2012 Jun 25. Diabetes. 2012. PMID: 22733797 Free PMC article.
Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction.
Sukumar P, Viswambharan H, Imrie H, Cubbon RM, Yuldasheva N, Gage M, Galloway S, Skromna A, Kandavelu P, Santos CX, Gatenby VK, Smith J, Beech DJ, Wheatcroft SB, Channon KM, Shah AM, Kearney MT. Sukumar P, et al. Among authors: galloway s. Diabetes. 2013 Jun;62(6):2130-4. doi: 10.2337/db12-1294. Epub 2013 Jan 24. Diabetes. 2013. PMID: 23349484 Free PMC article.
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species.
Gage MC, Yuldasheva NY, Viswambharan H, Sukumar P, Cubbon RM, Galloway S, Imrie H, Skromna A, Smith J, Jackson CL, Kearney MT, Wheatcroft SB. Gage MC, et al. Among authors: galloway s. Atherosclerosis. 2013 Sep;230(1):131-9. doi: 10.1016/j.atherosclerosis.2013.06.017. Epub 2013 Jun 29. Atherosclerosis. 2013. PMID: 23958265
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
Cubbon RM, Yuldasheva NY, Viswambharan H, Mercer BN, Baliga V, Stephen SL, Askham J, Sukumar P, Skromna A, Mughal RS, Walker AM, Bruns A, Bailey MA, Galloway S, Imrie H, Gage MC, Rakobowchuk M, Li J, Porter KE, Ponnambalam S, Wheatcroft SB, Beech DJ, Kearney MT. Cubbon RM, et al. Among authors: galloway s. Stem Cells. 2014 Oct;32(10):2714-23. doi: 10.1002/stem.1766. Stem Cells. 2014. PMID: 24916783 Free article.
Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.
Walker AMN, Warmke N, Mercer B, Watt NT, Mughal R, Smith J, Galloway S, Haywood NJ, Soomro T, Griffin KJ, Wheatcroft SB, Yuldasheva NY, Beech DJ, Carmeliet P, Kearney MT, Cubbon RM. Walker AMN, et al. Among authors: galloway s. Endocrinology. 2021 Aug 1;162(8):bqab104. doi: 10.1210/endocr/bqab104. Endocrinology. 2021. PMID: 34037749 Free PMC article.
515 results