Soderquist RS - Search Results

1

Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells.

Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. Wood M, et al. Among authors: soderquist rs. Mol Cancer Ther. 2011 Sep;10(9):1740-50. doi: 10.1158/1535-7163.MCT-11-0309. Epub 2011 Jun 22. Mol Cancer Ther. 2011. PMID: 21697395 Free PMC article.

2

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477.

Mallick DJ, Soderquist RS, Bates D, Eastman A. Mallick DJ, et al. Among authors: soderquist rs. Cell Death Dis. 2019 Feb 22;10(3):185. doi: 10.1038/s41419-019-1426-3. Cell Death Dis. 2019. PMID: 30796196 Free PMC article.

3

Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.

Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF, Eastman A. Albershardt TC, et al. Among authors: soderquist rs. J Biol Chem. 2011 Jul 15;286(28):24882-95. doi: 10.1074/jbc.M111.255828. Epub 2011 May 31. J Biol Chem. 2011. PMID: 21628457 Free PMC article.

4

Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.

Soderquist RS, Danilov AV, Eastman A. Soderquist RS, et al. J Biol Chem. 2014 Jun 6;289(23):16190-9. doi: 10.1074/jbc.M114.562900. Epub 2014 Apr 28. J Biol Chem. 2014. PMID: 24778183 Free PMC article.

5

The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA.

Soderquist R, Pletnev AA, Danilov AV, Eastman A. Soderquist R, et al. Apoptosis. 2014 Jan;19(1):201-9. doi: 10.1007/s10495-013-0910-y. Apoptosis. 2014. PMID: 24072590 Free PMC article.

6

Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells.

Paiva C, Godbersen JC, Soderquist RS, Rowland T, Kilmarx S, Spurgeon SE, Brown JR, Srinivasa SP, Danilov AV. Paiva C, et al. Among authors: soderquist rs. PLoS One. 2015 Nov 25;10(11):e0143685. doi: 10.1371/journal.pone.0143685. eCollection 2015. PLoS One. 2015. PMID: 26606677 Free PMC article.

7

Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo.

Soderquist R, Bates DJ, Danilov AV, Eastman A. Soderquist R, et al. Leukemia. 2013 Nov;27(11):2262-4. doi: 10.1038/leu.2013.138. Epub 2013 May 3. Leukemia. 2013. PMID: 23640104 Free PMC article. No abstract available.

8

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC. Anderson GR, et al. Among authors: soderquist rs. Sci Transl Med. 2016 Dec 14;8(369):369ra175. doi: 10.1126/scitranslmed.aae0348. Sci Transl Med. 2016. PMID: 27974663 Free PMC article.

9

Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells.

Ali M, Lu M, Ang HX, Soderquist RS, Eyler CE, Hutchinson HM, Glass C, Bassil CF, Lopez OM, Kerr DL, Falcon CJ, Yu HA, Hata AN, Blakely CM, McCoach CE, Bivona TG, Wood KC. Ali M, et al. Among authors: soderquist rs. Sci Transl Med. 2022 Mar 30;14(638):eabc7480. doi: 10.1126/scitranslmed.abc7480. Epub 2022 Mar 30. Sci Transl Med. 2022. PMID: 35353542 Free PMC article.

10

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity.

Soderquist RS, Crawford L, Liu E, Lu M, Agarwal A, Anderson GR, Lin KH, Winter PS, Cakir M, Wood KC. Soderquist RS, et al. Nat Commun. 2018 Aug 29;9(1):3513. doi: 10.1038/s41467-018-05815-z. Nat Commun. 2018. PMID: 30158527 Free PMC article.

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