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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. DeNicola GM, et al. Among authors: karreth fa. Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189. Nature. 2011. PMID: 21734707 Free PMC article.
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
King AJ, Patrick DR, Batorsky RS, Ho ML, Do HT, Zhang SY, Kumar R, Rusnak DW, Takle AK, Wilson DM, Hugger E, Wang L, Karreth F, Lougheed JC, Lee J, Chau D, Stout TJ, May EW, Rominger CM, Schaber MD, Luo L, Lakdawala AS, Adams JL, Contractor RG, Smalley KS, Herlyn M, Morrissey MM, Tuveson DA, Huang PS. King AJ, et al. Cancer Res. 2006 Dec 1;66(23):11100-5. doi: 10.1158/0008-5472.CAN-06-2554. Cancer Res. 2006. PMID: 17145850
Modelling oncogenic Ras/Raf signalling in the mouse.
Karreth FA, Tuveson DA. Karreth FA, et al. Curr Opin Genet Dev. 2009 Feb;19(1):4-11. doi: 10.1016/j.gde.2008.12.006. Epub 2009 Feb 7. Curr Opin Genet Dev. 2009. PMID: 19201597 Free PMC article. Review.
Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Skoulidis F, Cassidy LD, Pisupati V, Jonasson JG, Bjarnason H, Eyfjord JE, Karreth FA, Lim M, Barber LM, Clatworthy SA, Davies SE, Olive KP, Tuveson DA, Venkitaraman AR. Skoulidis F, et al. Among authors: karreth fa. Cancer Cell. 2010 Nov 16;18(5):499-509. doi: 10.1016/j.ccr.2010.10.015. Epub 2010 Nov 4. Cancer Cell. 2010. PMID: 21056012 Free article.
57 results