Klausz K - Search Results

1

Human kappa light chain targeted Pseudomonas exotoxin A--identifying human antibodies and Fab fragments with favorable characteristics for antibody-drug conjugate development.

Kellner C, Bleeker WK, Lammerts van Bueren JJ, Staudinger M, Klausz K, Derer S, Glorius P, Muskulus A, de Goeij BE, van de Winkel JG, Parren PW, Valerius T, Gramatzki M, Peipp M. Kellner C, et al. Among authors: klausz k. J Immunol Methods. 2011 Aug 31;371(1-2):122-33. doi: 10.1016/j.jim.2011.06.023. Epub 2011 Jun 30. J Immunol Methods. 2011. PMID: 21756911

2

Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells.

Schlaeth M, Berger S, Derer S, Klausz K, Lohse S, Dechant M, Lazar GA, Schneider-Merck T, Peipp M, Valerius T. Schlaeth M, et al. Among authors: klausz k. Cancer Sci. 2010 May;101(5):1080-8. doi: 10.1111/j.1349-7006.2010.01505.x. Epub 2010 Jan 20. Cancer Sci. 2010. PMID: 20331636 Free PMC article.

3

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.

Lohse S, Derer S, Beyer T, Klausz K, Peipp M, Leusen JH, van de Winkel JG, Dechant M, Valerius T. Lohse S, et al. Among authors: klausz k. J Immunol. 2011 Mar 15;186(6):3770-8. doi: 10.4049/jimmunol.1003082. Epub 2011 Feb 11. J Immunol. 2011. PMID: 21317397

4

Complement-mediated tumor-specific cell lysis by antibody combinations targeting epidermal growth factor receptor (EGFR) and its variant III (EGFRvIII).

Klausz K, Berger S, Lammerts van Bueren JJ, Derer S, Lohse S, Dechant M, van de Winkel JG, Peipp M, Parren PW, Valerius T. Klausz K, et al. Cancer Sci. 2011 Oct;102(10):1761-8. doi: 10.1111/j.1349-7006.2011.02019.x. Epub 2011 Aug 4. Cancer Sci. 2011. PMID: 21718386 Free article.

5

Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression.

Derer S, Berger S, Schlaeth M, Schneider-Merck T, Klausz K, Lohse S, Overdijk MB, Dechant M, Kellner C, Nagelmeier I, Scheel AH, Lammerts van Bueren JJ, van de Winkel JG, Parren PW, Peipp M, Valerius T. Derer S, et al. Among authors: klausz k. Neoplasia. 2012 Mar;14(3):190-205. doi: 10.1593/neo.111636. Neoplasia. 2012. PMID: 22496619 Free PMC article.

6

ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.

Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J. Trad A, et al. Among authors: klausz k. Cancer Immunol Immunother. 2013 Mar;62(3):411-21. doi: 10.1007/s00262-012-1346-x. Epub 2012 Sep 1. Cancer Immunol Immunother. 2013. PMID: 22940887 Free PMC article.

7

Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity.

Derer S, Glorius P, Schlaeth M, Lohse S, Klausz K, Muchhal U, Desjarlais JR, Humpe A, Valerius T, Peipp M. Derer S, et al. Among authors: klausz k. MAbs. 2014 Mar-Apr;6(2):409-21. doi: 10.4161/mabs.27457. Epub 2013 Dec 11. MAbs. 2014. PMID: 24492248 Free PMC article.

8

Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization.

Derer S, Kellner C, Rösner T, Klausz K, Glorius P, Valerius T, Peipp M. Derer S, et al. Among authors: klausz k. Methods Mol Biol. 2014;1131:525-40. doi: 10.1007/978-1-62703-992-5_33. Methods Mol Biol. 2014. PMID: 24515488

9

The novel immunotoxin HM1.24-ETA' induces apoptosis in multiple myeloma cells.

Staudinger M, Glorius P, Burger R, Kellner C, Klausz K, Günther A, Repp R, Klapper W, Gramatzki M, Peipp M. Staudinger M, et al. Among authors: klausz k. Blood Cancer J. 2014 Jun 13;4(6):e219. doi: 10.1038/bcj.2014.38. Blood Cancer J. 2014. PMID: 24927408 Free PMC article.

10

The novel multispecies Fc-specific Pseudomonas exotoxin A fusion protein α-Fc-ETA' enables screening of antibodies for immunotoxin development.

Klausz K, Kellner C, Derer S, Valerius T, Staudinger M, Burger R, Gramatzki M, Peipp M. Klausz K, et al. J Immunol Methods. 2015 Mar;418:75-83. doi: 10.1016/j.jim.2015.02.002. Epub 2015 Feb 18. J Immunol Methods. 2015. PMID: 25701195

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