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L-Ala-γ-D-Glu-meso-diaminopimelic acid (DAP) interacts directly with leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its interaction with nucleotide-binding oligomerization domain 1.
Laroui H, Yan Y, Narui Y, Ingersoll SA, Ayyadurai S, Charania MA, Zhou F, Wang B, Salaita K, Sitaraman SV, Merlin D. Laroui H, et al. Among authors: ingersoll sa. J Biol Chem. 2011 Sep 2;286(35):31003-31013. doi: 10.1074/jbc.M111.257501. Epub 2011 Jul 12. J Biol Chem. 2011. PMID: 21757725 Free PMC article.
The PepT1-NOD2 signaling pathway aggravates induced colitis in mice.
Dalmasso G, Nguyen HT, Ingersoll SA, Ayyadurai S, Laroui H, Charania MA, Yan Y, Sitaraman SV, Merlin D. Dalmasso G, et al. Among authors: ingersoll sa. Gastroenterology. 2011 Oct;141(4):1334-45. doi: 10.1053/j.gastro.2011.06.080. Epub 2011 Jul 14. Gastroenterology. 2011. PMID: 21762661 Free PMC article.
Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model.
Viennois E, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang M, Han MK, Garg P, Xiao B, Merlin D. Viennois E, et al. Among authors: ingersoll sa. Cell Mol Gastroenterol Hepatol. 2016 May;2(3):340-357. doi: 10.1016/j.jcmgh.2016.01.006. Cell Mol Gastroenterol Hepatol. 2016. PMID: 27458604 Free PMC article.
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