Steyn SJ - Search Results

1

Modulation of NMDA receptor function by inhibition of D-amino acid oxidase in rodent brain.

Strick CA, Li C, Scott L, Harvey B, Hajós M, Steyn SJ, Piotrowski MA, James LC, Downs JT, Rago B, Becker SL, El-Kattan A, Xu Y, Ganong AH, Tingley FD 3rd, Ramirez AD, Seymour PA, Guanowsky V, Majchrzak MJ, Fox CB, Schmidt CJ, Duplantier AJ. Strick CA, et al. Among authors: steyn sj. Neuropharmacology. 2011 Oct-Nov;61(5-6):1001-15. doi: 10.1016/j.neuropharm.2011.06.029. Epub 2011 Jul 7. Neuropharmacology. 2011. PMID: 21763704

2

Selective inhibition of MAO-B through chronic low-dose (R)-deprenyl treatment in C57BL/6 mice has no effect on basal neostriatal dopamine levels.

Steyn SJ, Castagnoli K, Steyn S, Castagnoli N Jr. Steyn SJ, et al. Among authors: steyn s. Exp Neurol. 2001 Apr;168(2):434-6. doi: 10.1006/exnr.2000.7610. Exp Neurol. 2001. PMID: 11259132

3

Measurement of mitochondrial respiration in permeabilized murine neuroblastoma (N-2alpha) cells, a simple and rapid in situ assay to investigate mitochondrial toxins.

Steyn SJ, Pieterse DJ, Mienie LJ, Van der Schyf CJ. Steyn SJ, et al. J Biochem Biophys Methods. 2005 Jan 31;62(1):25-40. doi: 10.1016/j.jbbm.2004.07.002. Epub 2004 Sep 23. J Biochem Biophys Methods. 2005. PMID: 15656941

4

Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.

Duplantier AJ, Becker SL, Bohanon MJ, Borzilleri KA, Chrunyk BA, Downs JT, Hu LY, El-Kattan A, James LC, Liu S, Lu J, Maklad N, Mansour MN, Mente S, Piotrowski MA, Sakya SM, Sheehan S, Steyn SJ, Strick CA, Williams VA, Zhang L. Duplantier AJ, et al. Among authors: steyn sj. J Med Chem. 2009 Jun 11;52(11):3576-85. doi: 10.1021/jm900128w. J Med Chem. 2009. PMID: 19438227

5

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD. Varma MV, et al. Among authors: steyn sj. J Med Chem. 2010 Feb 11;53(3):1098-108. doi: 10.1021/jm901371v. J Med Chem. 2010. PMID: 20070106

6

pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery.

Varma MV, Gardner I, Steyn SJ, Nkansah P, Rotter CJ, Whitney-Pickett C, Zhang H, Di L, Cram M, Fenner KS, El-Kattan AF. Varma MV, et al. Among authors: steyn sj. Mol Pharm. 2012 May 7;9(5):1199-212. doi: 10.1021/mp2004912. Epub 2012 Apr 26. Mol Pharm. 2012. PMID: 22489626

7

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).

Varma MV, Steyn SJ, Allerton C, El-Kattan AF. Varma MV, et al. Among authors: steyn sj. Pharm Res. 2015 Dec;32(12):3785-802. doi: 10.1007/s11095-015-1749-4. Epub 2015 Jul 9. Pharm Res. 2015. PMID: 26155985

8

Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M₁ Receptor Activation.

Popiolek M, Nguyen DP, Reinhart V, Edgerton JR, Harms J, Lotarski SM, Steyn SJ, Davoren JE, Grimwood S. Popiolek M, et al. Among authors: steyn sj. Biochemistry. 2016 Dec 27;55(51):7073-7085. doi: 10.1021/acs.biochem.6b00688. Epub 2016 Dec 13. Biochemistry. 2016. PMID: 27958713

9

Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.

Galatsis P, Henderson JL, Kormos BL, Han S, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD. Galatsis P, et al. Among authors: steyn sj. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4132-40. doi: 10.1016/j.bmcl.2014.07.052. Epub 2014 Jul 30. Bioorg Med Chem Lett. 2014. PMID: 25113930

10

Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.

Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, Galatsis P. Henderson JL, et al. Among authors: steyn sj. J Med Chem. 2015 Jan 8;58(1):419-32. doi: 10.1021/jm5014055. Epub 2014 Nov 17. J Med Chem. 2015. PMID: 25353650

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