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Page 1
Oxidized CaMKII causes cardiac sinus node dysfunction in mice.
Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Swaminathan PD, et al. Among authors: gao z. J Clin Invest. 2011 Aug;121(8):3277-88. doi: 10.1172/JCI57833. Epub 2011 Jul 25. J Clin Invest. 2011. PMID: 21785215 Free PMC article.
Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Wu Y, et al. Among authors: gao z. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5972-7. doi: 10.1073/pnas.0806422106. Epub 2009 Mar 10. Proc Natl Acad Sci U S A. 2009. PMID: 19276108 Free PMC article.
CaMKII determines mitochondrial stress responses in heart.
Joiner ML, Koval OM, Li J, He BJ, Allamargot C, Gao Z, Luczak ED, Hall DD, Fink BD, Chen B, Yang J, Moore SA, Scholz TD, Strack S, Mohler PJ, Sivitz WI, Song LS, Anderson ME. Joiner ML, et al. Among authors: gao z. Nature. 2012 Nov 8;491(7423):269-73. doi: 10.1038/nature11444. Epub 2012 Oct 10. Nature. 2012. PMID: 23051746 Free PMC article.
Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate.
Gao Z, Rasmussen TP, Li Y, Kutschke W, Koval OM, Wu Y, Wu Y, Hall DD, Joiner ML, Wu XQ, Swaminathan PD, Purohit A, Zimmerman K, Weiss RM, Philipson KD, Song LS, Hund TJ, Anderson ME. Gao Z, et al. Circ Res. 2013 Jan 18;112(2):309-17. doi: 10.1161/CIRCRESAHA.111.300193. Epub 2012 Nov 27. Circ Res. 2013. PMID: 23192947 Free PMC article.
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
Luo M, Guan X, Luczak ED, Lang D, Kutschke W, Gao Z, Yang J, Glynn P, Sossalla S, Swaminathan PD, Weiss RM, Yang B, Rokita AG, Maier LS, Efimov IR, Hund TJ, Anderson ME. Luo M, et al. Among authors: gao z. J Clin Invest. 2013 Mar;123(3):1262-74. doi: 10.1172/JCI65268. Epub 2013 Feb 15. J Clin Invest. 2013. PMID: 23426181 Free PMC article.
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Purohit A, et al. Among authors: gao z. Circulation. 2013 Oct 15;128(16):1748-57. doi: 10.1161/CIRCULATIONAHA.113.003313. Epub 2013 Sep 12. Circulation. 2013. PMID: 24030498 Free PMC article.
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