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Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.
Labbadia J, Cunliffe H, Weiss A, Katsyuba E, Sathasivam K, Seredenina T, Woodman B, Moussaoui S, Frentzel S, Luthi-Carter R, Paganetti P, Bates GP. Labbadia J, et al. Among authors: paganetti p. J Clin Invest. 2011 Aug;121(8):3306-19. doi: 10.1172/JCI57413. Epub 2011 Jul 25. J Clin Invest. 2011. PMID: 21785217 Free PMC article.
Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.
Landles C, Sathasivam K, Weiss A, Woodman B, Moffitt H, Finkbeiner S, Sun B, Gafni J, Ellerby LM, Trottier Y, Richards WG, Osmand A, Paganetti P, Bates GP. Landles C, et al. Among authors: paganetti p. J Biol Chem. 2010 Mar 19;285(12):8808-23. doi: 10.1074/jbc.M109.075028. Epub 2010 Jan 19. J Biol Chem. 2010. PMID: 20086007 Free PMC article.
94 results