Turkson J - Search Results

1

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain.

Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT. Page BD, et al. Among authors: turkson j. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5605-9. doi: 10.1016/j.bmcl.2011.06.056. Epub 2011 Jun 30. Bioorg Med Chem Lett. 2011. PMID: 21788134 Free PMC article.

2

Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.

Anagnostopoulou A, Vultur A, Arulanandam R, Cao J, Turkson J, Jove R, Kim JS, Glenn M, Hamilton AD, Raptis L. Anagnostopoulou A, et al. Among authors: turkson j. Cancer Lett. 2006 Oct 8;242(1):120-32. doi: 10.1016/j.canlet.2005.10.047. Epub 2005 Dec 27. Cancer Lett. 2006. PMID: 16377083

3

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: turkson j. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. doi: 10.1016/j.bmcl.2007.01.077. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17336521

4

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Sebti SM, Jove R, Hamilton AD, Turkson J. Siddiquee KA, et al. Among authors: turkson j. ACS Chem Biol. 2007 Dec 21;2(12):787-98. doi: 10.1021/cb7001973. ACS Chem Biol. 2007. PMID: 18154266

5

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein.

Fletcher S, Turkson J, Gunning PT. Fletcher S, et al. Among authors: turkson j. ChemMedChem. 2008 Aug;3(8):1159-68. doi: 10.1002/cmdc.200800123. ChemMedChem. 2008. PMID: 18683176 Free PMC article. Review. No abstract available.

6

Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders.

Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Among authors: turkson j. Chembiochem. 2008 Nov 24;9(17):2800-3. doi: 10.1002/cbic.200800291. Chembiochem. 2008. PMID: 19006150 Free PMC article. No abstract available.

7

Targeting STAT3 in cancer: how successful are we?

Yue P, Turkson J. Yue P, et al. Among authors: turkson j. Expert Opin Investig Drugs. 2009 Jan;18(1):45-56. doi: 10.1517/13543780802565791. Expert Opin Investig Drugs. 2009. PMID: 19053881 Free PMC article. Review.

8

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Fletcher S, Singh J, Zhang X, Yue P, Page BD, Sharmeen S, Shahani VM, Zhao W, Schimmer AD, Turkson J, Gunning PT. Fletcher S, et al. Among authors: turkson j. Chembiochem. 2009 Aug 17;10(12):1959-64. doi: 10.1002/cbic.200900172. Chembiochem. 2009. PMID: 19644994 Free PMC article. No abstract available.

9

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes.

Zhang X, Yue P, Fletcher S, Zhao W, Gunning PT, Turkson J. Zhang X, et al. Among authors: turkson j. Biochem Pharmacol. 2010 May 15;79(10):1398-409. doi: 10.1016/j.bcp.2010.01.001. Epub 2010 Jan 11. Biochem Pharmacol. 2010. PMID: 20067773 Free PMC article.

10

Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src.

Jaganathan S, Yue P, Turkson J. Jaganathan S, et al. Among authors: turkson j. J Pharmacol Exp Ther. 2010 May;333(2):373-81. doi: 10.1124/jpet.109.162669. Epub 2010 Jan 25. J Pharmacol Exp Ther. 2010. PMID: 20100905 Free PMC article.

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