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Angiotensin II contributes to podocyte injury by increasing TRPC6 expression via an NFAT-mediated positive feedback signaling pathway.
Nijenhuis T, Sloan AJ, Hoenderop JG, Flesche J, van Goor H, Kistler AD, Bakker M, Bindels RJ, de Boer RA, Möller CC, Hamming I, Navis G, Wetzels JF, Berden JH, Reiser J, Faul C, van der Vlag J. Nijenhuis T, et al. Among authors: faul c. Am J Pathol. 2011 Oct;179(4):1719-32. doi: 10.1016/j.ajpath.2011.06.033. Epub 2011 Aug 11. Am J Pathol. 2011. PMID: 21839714 Free PMC article.
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.
Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. Reiser J, et al. Among authors: faul c. Nat Genet. 2005 Jul;37(7):739-44. doi: 10.1038/ng1592. Epub 2005 May 27. Nat Genet. 2005. PMID: 15924139 Free PMC article.
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, Reinheckel T, Gu C, Huber TB, Ju W, Bitzer M, Rastaldi MP, Ruiz P, Tryggvason K, Shaw AS, Faul C, Sever S, Reiser J. Yaddanapudi S, et al. Among authors: faul c. J Clin Invest. 2011 Oct;121(10):3965-80. doi: 10.1172/JCI58552. Epub 2011 Sep 12. J Clin Invest. 2011. PMID: 21911934 Free PMC article.
TRPC6 in podocytes: questions and commentary on the article by Jiang et al., 'Over-expressing transient receptor potential cation channel 6 in podocytes induces cytoskeleton rearrangement through increases of intracellular Ca21 and RhoA activation'.
Kistler AD, Faul C, Reiser J. Kistler AD, et al. Among authors: faul c. Exp Biol Med (Maywood). 2011 Dec;236(12):1361; author reply 1362-3. doi: 10.1258/ebm.2011.011c01. Exp Biol Med (Maywood). 2011. PMID: 22242226 No abstract available.
Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.
Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, Faul C, Reiser J. Kistler AD, et al. Among authors: faul c. J Biol Chem. 2013 Dec 20;288(51):36598-609. doi: 10.1074/jbc.M113.488122. Epub 2013 Nov 5. J Biol Chem. 2013. PMID: 24194522 Free PMC article.
293 results