Lehmkuhl K - Search Results

1

Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.

Schläger T, Schepmann D, Lehmkuhl K, Holenz J, Vela JM, Buschmann H, Wünsch B. Schläger T, et al. Among authors: lehmkuhl k. J Med Chem. 2011 Oct 13;54(19):6704-13. doi: 10.1021/jm200585k. Epub 2011 Sep 16. J Med Chem. 2011. PMID: 21859078

2

Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.

Geiger C, Zelenka C, Weigl M, Fröhlich R, Wibbeling B, Lehmkuhl K, Schepmann D, Grünert R, Bednarski PJ, Wünsch B. Geiger C, et al. Among authors: lehmkuhl k. J Med Chem. 2007 Nov 29;50(24):6144-53. doi: 10.1021/jm070620b. Epub 2007 Oct 30. J Med Chem. 2007. PMID: 17967001

3

Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety.

Jung B, Englberger W, Fröhlich R, Schepmann D, Lehmkuhl K, Wünsch B. Jung B, et al. Among authors: lehmkuhl k. Bioorg Med Chem. 2008 Mar 15;16(6):2870-85. doi: 10.1016/j.bmc.2008.01.004. Epub 2008 Jan 10. Bioorg Med Chem. 2008. PMID: 18249546

4

Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.

Jasper A, Schepmann D, Lehmkuhl K, Vela JM, Buschmann H, Holenz J, Wünsch B. Jasper A, et al. Among authors: lehmkuhl k. Eur J Med Chem. 2009 Nov;44(11):4306-14. doi: 10.1016/j.ejmech.2009.07.017. Epub 2009 Jul 21. Eur J Med Chem. 2009. PMID: 19709783

5

Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.

Geiger C, Zelenka C, Lehmkuhl K, Schepmann D, Englberger W, Wünsch B. Geiger C, et al. Among authors: lehmkuhl k. J Med Chem. 2010 May 27;53(10):4212-22. doi: 10.1021/jm100182p. J Med Chem. 2010. PMID: 20441176

6

Microwave assisted synthesis of spirocyclic pyrrolidines -σ1 receptor ligands with modified benzene-N-distance.

Jasper A, Schepmann D, Lehmkuhl K, Vela JM, Buschmann H, Holenz J, Wünsch B. Jasper A, et al. Among authors: lehmkuhl k. Eur J Med Chem. 2012 Jul;53:327-36. doi: 10.1016/j.ejmech.2012.04.018. Epub 2012 Apr 21. Eur J Med Chem. 2012. PMID: 22578786

7

Design, synthesis and receptor affinity of novel conformationally restricted σ ligands based on the [4.3.3]propellane scaffold.

Torres-Gómez H, Lehmkuhl K, Schepmann D, Wünsch B. Torres-Gómez H, et al. Among authors: lehmkuhl k. Eur J Med Chem. 2013;70:78-87. doi: 10.1016/j.ejmech.2013.09.021. Epub 2013 Sep 27. Eur J Med Chem. 2013. PMID: 24140950

8

Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position.

Hasebein P, Frehland B, Lehmkuhl K, Fröhlich R, Schepmann D, Wünsch B. Hasebein P, et al. Among authors: lehmkuhl k. Org Biomol Chem. 2014 Aug 7;12(29):5407-26. doi: 10.1039/c4ob00510d. Org Biomol Chem. 2014. PMID: 24934693

9

Synthesis and pharmacological evaluation of 5-pyrrolidinylquinoxalines as a novel class of peripherally restricted κ-opioid receptor agonists.

Bourgeois C, Werfel E, Galla F, Lehmkuhl K, Torres-Gómez H, Schepmann D, Kögel B, Christoph T, Straßburger W, Englberger W, Soeberdt M, Hüwel S, Galla HJ, Wünsch B. Bourgeois C, et al. Among authors: lehmkuhl k. J Med Chem. 2014 Aug 14;57(15):6845-60. doi: 10.1021/jm500940q. Epub 2014 Aug 5. J Med Chem. 2014. PMID: 25062506

10

Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.

Torres-Gómez H, Lehmkuhl K, Frehland B, Daniliuc C, Schepmann D, Ehrhardt C, Wünsch B. Torres-Gómez H, et al. Among authors: lehmkuhl k. Bioorg Med Chem. 2015 Aug 1;23(15):4277-4285. doi: 10.1016/j.bmc.2015.06.030. Epub 2015 Jun 18. Bioorg Med Chem. 2015. PMID: 26145819

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