Kojima K - Search Results

1

p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.

Kojima K, McQueen T, Chen Y, Jacamo R, Konopleva M, Shinojima N, Shpall E, Huang X, Andreeff M. Kojima K, et al. Blood. 2011 Oct 20;118(16):4431-9. doi: 10.1182/blood-2011-02-334136. Epub 2011 Aug 25. Blood. 2011. PMID: 21868571 Free PMC article.

2

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy.

Kojima K, Konopleva M, Samudio IJ, Shikami M, Cabreira-Hansen M, McQueen T, Ruvolo V, Tsao T, Zeng Z, Vassilev LT, Andreeff M. Kojima K, et al. Blood. 2005 Nov 1;106(9):3150-9. doi: 10.1182/blood-2005-02-0553. Epub 2005 Jul 12. Blood. 2005. PMID: 16014563 Free PMC article.

3

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.

Kojima K, Konopleva M, McQueen T, O'Brien S, Plunkett W, Andreeff M. Kojima K, et al. Blood. 2006 Aug 1;108(3):993-1000. doi: 10.1182/blood-2005-12-5148. Epub 2006 Mar 16. Blood. 2006. PMID: 16543464 Free PMC article.

4

Concomitant inhibition of MDM2 and Bcl-2 protein function synergistically induce mitochondrial apoptosis in AML.

Kojima K, Konopleva M, Samudio IJ, Schober WD, Bornmann WG, Andreeff M. Kojima K, et al. Cell Cycle. 2006 Dec;5(23):2778-86. doi: 10.4161/cc.5.23.3520. Epub 2006 Dec 1. Cell Cycle. 2006. PMID: 17172851

5

Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.

Kojima K, Konopleva M, Samudio IJ, Ruvolo V, Andreeff M. Kojima K, et al. Cancer Res. 2007 Apr 1;67(7):3210-9. doi: 10.1158/0008-5472.CAN-06-2712. Cancer Res. 2007. PMID: 17409429

6

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

Kojima K, Shimanuki M, Shikami M, Samudio IJ, Ruvolo V, Corn P, Hanaoka N, Konopleva M, Andreeff M, Nakakuma H. Kojima K, et al. Leukemia. 2008 Sep;22(9):1728-36. doi: 10.1038/leu.2008.158. Epub 2008 Jun 12. Leukemia. 2008. PMID: 18548093

7

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia.

Kojima K, Konopleva M, Tsao T, Nakakuma H, Andreeff M. Kojima K, et al. Blood. 2008 Oct 1;112(7):2886-95. doi: 10.1182/blood-2008-01-128611. Epub 2008 Jul 16. Blood. 2008. PMID: 18633130 Free PMC article.

8

Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.

Kojima K, Shimanuki M, Shikami M, Andreeff M, Nakakuma H. Kojima K, et al. Cancer Sci. 2009 Jun;100(6):1128-36. doi: 10.1111/j.1349-7006.2009.01150.x. Epub 2009 Mar 10. Cancer Sci. 2009. PMID: 19385969 Free PMC article.

9

Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis.

Kojima K, Konopleva M, Tsao T, Andreeff M, Ishida H, Shiotsu Y, Jin L, Tabe Y, Nakakuma H. Kojima K, et al. Leukemia. 2010 Jan;24(1):33-43. doi: 10.1038/leu.2009.212. Epub 2009 Oct 15. Leukemia. 2010. PMID: 19946262

10

The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.

Kojima K, Burks JK, Arts J, Andreeff M. Kojima K, et al. Mol Cancer Ther. 2010 Sep;9(9):2545-57. doi: 10.1158/1535-7163.MCT-10-0337. Epub 2010 Aug 24. Mol Cancer Ther. 2010. PMID: 20736344 Free PMC article.

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