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MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
Mäkinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ, Gentile M, Yan J, Enge M, Taipale M, Aavikko M, Katainen R, Virolainen E, Böhling T, Koski TA, Launonen V, Sjöberg J, Taipale J, Vahteristo P, Aaltonen LA. Mäkinen N, et al. Among authors: bohling t. Science. 2011 Oct 14;334(6053):252-5. doi: 10.1126/science.1208930. Epub 2011 Aug 25. Science. 2011. PMID: 21868628
No evidence of microsatellite instability in bone tumours.
Tarkkanen M, Aaltonen LA, Böhling T, Kivioja A, Karaharju E, Elomaa I, Knuutila S. Tarkkanen M, et al. Among authors: bohling t. Br J Cancer. 1996 Aug;74(3):453-5. doi: 10.1038/bjc.1996.380. Br J Cancer. 1996. PMID: 8695363 Free PMC article.
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
Kämpjärvi K, Mäkinen N, Kilpivaara O, Arola J, Heinonen HR, Böhm J, Abdel-Wahab O, Lehtonen HJ, Pelttari LM, Mehine M, Schrewe H, Nevanlinna H, Levine RL, Hokland P, Böhling T, Mecklin JP, Bützow R, Aaltonen LA, Vahteristo P. Kämpjärvi K, et al. Among authors: bohling t. Br J Cancer. 2012 Nov 6;107(10):1761-5. doi: 10.1038/bjc.2012.428. Epub 2012 Sep 20. Br J Cancer. 2012. PMID: 23132392 Free PMC article.
Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.
Kämpjärvi K, Park MJ, Mehine M, Kim NH, Clark AD, Bützow R, Böhling T, Böhm J, Mecklin JP, Järvinen H, Tomlinson IP, van der Spuy ZM, Sjöberg J, Boyer TG, Vahteristo P. Kämpjärvi K, et al. Among authors: bohling t. Hum Mutat. 2014 Sep;35(9):1136-41. doi: 10.1002/humu.22612. Epub 2014 Jul 21. Hum Mutat. 2014. PMID: 24980722
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
Kämpjärvi K, Kim NH, Keskitalo S, Clark AD, von Nandelstadh P, Turunen M, Heikkinen T, Park MJ, Mäkinen N, Kivinummi K, Lintula S, Hotakainen K, Nevanlinna H, Hokland P, Böhling T, Bützow R, Böhm J, Mecklin JP, Järvinen H, Kontro M, Visakorpi T, Taipale J, Varjosalo M, Boyer TG, Vahteristo P. Kämpjärvi K, et al. Among authors: bohling t. Prostate. 2016 Jan;76(1):22-31. doi: 10.1002/pros.23092. Epub 2015 Sep 18. Prostate. 2016. PMID: 26383637
New Insights into the Cellular Pathways Affected in Primary Uterine Leiomyosarcoma.
Kaur S, Larramendy ML, Gentile M, Svarvar C, Koivisto-Korander R, Vauhkonen H, Scheinin I, Leminen A, Bützow R, Böhling T, Knuutila S. Kaur S, et al. Among authors: bohling t. Cancer Genomics Proteomics. 2006 Nov-Dec;3(6):347-354. Epub 2006 Nov 1. Cancer Genomics Proteomics. 2006. PMID: 31394667 Free article.
CanGEM: mining gene copy number changes in cancer.
Scheinin I, Myllykangas S, Borze I, Böhling T, Knuutila S, Saharinen J. Scheinin I, et al. Among authors: bohling t. Nucleic Acids Res. 2008 Jan;36(Database issue):D830-5. doi: 10.1093/nar/gkm802. Epub 2007 Oct 11. Nucleic Acids Res. 2008. PMID: 17932056 Free PMC article.
193 results