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Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans.
Bucci M, Borra R, Någren K, Pärkkä JP, Del Ry S, Maggio R, Tuunanen H, Viljanen T, Cabiati M, Rigazio S, Taittonen M, Pagotto U, Parkkola R, Opie LH, Nuutila P, Knuuti J, Iozzo P. Bucci M, et al. Among authors: rigazio s. Cardiovasc Ther. 2012 Dec;30(6):333-41. doi: 10.1111/j.1755-5922.2011.00275.x. Epub 2011 Jul 31. Cardiovasc Ther. 2012. PMID: 21884010 Free article.
Human obesity is characterized by defective fat storage and enhanced muscle fatty acid oxidation, and trimetazidine gradually counteracts these abnormalities.
Bucci M, Borra R, Någren K, Maggio R, Tuunanen H, Oikonen V, Del Ry S, Viljanen T, Taittonen M, Rigazio S, Giannessi D, Parkkola R, Knuuti J, Nuutila P, Iozzo P. Bucci M, et al. Among authors: rigazio s. Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E105-12. doi: 10.1152/ajpendo.00680.2010. Epub 2011 Apr 19. Am J Physiol Endocrinol Metab. 2011. PMID: 21505146 Free article. Clinical Trial.