Chalmers MJ - Search Results

1

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, Vidović D, Shulman GI, Spiegelman BM, Griffin PR. Choi JH, et al. Among authors: chalmers mj. Nature. 2011 Sep 4;477(7365):477-81. doi: 10.1038/nature10383. Nature. 2011. PMID: 21892191 Free PMC article.

2

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Choi JH, et al. Among authors: chalmers mj. Nature. 2010 Jul 22;466(7305):451-6. doi: 10.1038/nature09291. Nature. 2010. PMID: 20651683 Free PMC article.

3

Partial agonists activate PPARgamma using a helix 12 independent mechanism.

Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Bruning JB, et al. Among authors: chalmers mj. Structure. 2007 Oct;15(10):1258-71. doi: 10.1016/j.str.2007.07.014. Structure. 2007. PMID: 17937915 Free article.

4

Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors.

Malapaka RRV, Khoo S, Zhang J, Choi JH, Zhou XE, Xu Y, Gong Y, Li J, Yong EL, Chalmers MJ, Chang L, Resau JH, Griffin PR, Chen YE, Xu HE. Malapaka RRV, et al. Among authors: chalmers mj. J Biol Chem. 2012 Jan 2;287(1):183-195. doi: 10.1074/jbc.M111.294785. Epub 2011 Oct 28. J Biol Chem. 2012. PMID: 22039047 Free PMC article.

5

Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.

Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM. Devarakonda S, et al. Among authors: chalmers mj. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18678-83. doi: 10.1073/pnas.1113813108. Epub 2011 Nov 2. Proc Natl Acad Sci U S A. 2011. PMID: 22049338 Free PMC article.

6

Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.

Hughes TS, Chalmers MJ, Novick S, Kuruvilla DS, Chang MR, Kamenecka TM, Rance M, Johnson BA, Burris TP, Griffin PR, Kojetin DJ. Hughes TS, et al. Among authors: chalmers mj. Structure. 2012 Jan 11;20(1):139-50. doi: 10.1016/j.str.2011.10.018. Structure. 2012. PMID: 22244763 Free PMC article.

7

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.

Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Kojetin DJ, et al. Among authors: chalmers mj. Nat Commun. 2015 Aug 20;6:8013. doi: 10.1038/ncomms9013. Nat Commun. 2015. PMID: 26289479 Free PMC article.

8

DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.

Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Wang Y, Busby SA, Pascal BD, Garcia-Ordonez RD, Bruning JB, Istrate MA, Kojetin DJ, Dodge JA, Burris TP, Griffin PR. Zhang J, et al. Among authors: chalmers mj. Nat Struct Mol Biol. 2011 May;18(5):556-63. doi: 10.1038/nsmb.2046. Epub 2011 Apr 10. Nat Struct Mol Biol. 2011. PMID: 21478866 Free PMC article.

9

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Zheng J, Chang MR, Stites RE, Wang Y, Bruning JB, Pascal BD, Novick SJ, Garcia-Ordonez RD, Stayrook KR, Chalmers MJ, Dodge JA, Griffin PR. Zheng J, et al. Among authors: chalmers mj. Nat Commun. 2017 Oct 13;8(1):923. doi: 10.1038/s41467-017-00978-7. Nat Commun. 2017. PMID: 29030554 Free PMC article.

10

Automated hydrogen/deuterium exchange electron transfer dissociation high resolution mass spectrometry measured at single-amide resolution.

Landgraf RR, Chalmers MJ, Griffin PR. Landgraf RR, et al. Among authors: chalmers mj. J Am Soc Mass Spectrom. 2012 Feb;23(2):301-9. doi: 10.1007/s13361-011-0298-2. Epub 2011 Dec 1. J Am Soc Mass Spectrom. 2012. PMID: 22131230 Free PMC article.

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