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Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, Collins MP, Davies AM, Deegan T, Ezhuthachan J, Filla S, Freed E, Hu H, Huszar D, Jayaraman M, Lawson D, Lewis PM, Nadella MV, Oza V, Padmanilayam M, Pontz T, Ronco L, Russell D, Whitston D, Zheng X. Theoclitou ME, et al. Among authors: freed e. J Med Chem. 2011 Oct 13;54(19):6734-50. doi: 10.1021/jm200629m. Epub 2011 Sep 7. J Med Chem. 2011. PMID: 21899292
Analgesic agents. 3. New bridged aminotetralins.
Freed ME, Potoski JR, Freed EH, Conklin GL, Bell SC. Freed ME, et al. Among authors: freed eh. J Med Chem. 1976 Apr;19(4):476-80. doi: 10.1021/jm00226a005. J Med Chem. 1976. PMID: 1263200 No abstract available.
Bridged amino tetralins.
Freed ME, Potoski JR, Freed EH, Gluckman MI, Malis JL. Freed ME, et al. Among authors: freed eh. Adv Biochem Psychopharmacol. 1973;8(0):137-44. Adv Biochem Psychopharmacol. 1973. PMID: 4211844 No abstract available.
Bridged aminotetralins as novel potent analgesic sunstances.
Freed ME, Potoski JR, Freed EH, Conklin GL, Malis JL. Freed ME, et al. Among authors: freed eh. J Med Chem. 1973 Jun;16(6):595-9. doi: 10.1021/jm00264a003. J Med Chem. 1973. PMID: 4714986 No abstract available.
Exploring HIV-1 Maturation: A New Frontier in Antiviral Development.
McGraw A, Hillmer G, Medehincu SM, Hikichi Y, Gagliardi S, Narayan K, Tibebe H, Marquez D, Mei Bose L, Keating A, Izumi C, Peese K, Joshi S, Krystal M, DeCicco-Skinner KL, Freed EO, Sardo L, Izumi T. McGraw A, et al. Among authors: freed eo. Viruses. 2024 Sep 6;16(9):1423. doi: 10.3390/v16091423. Viruses. 2024. PMID: 39339899 Free PMC article. Review.
A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.
NIHR Global Health Research Unit on Global Surgery; STARSurg Collaborative. NIHR Global Health Research Unit on Global Surgery, et al. Lancet Digit Health. 2024 Jul;6(7):e507-e519. doi: 10.1016/S2589-7500(24)00065-7. Lancet Digit Health. 2024. PMID: 38906616 Free article.
355 results